Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

Unlike conventional itch, neuropathic itch develops in normal skin from excess peripheral
firing or dampened central inhibition of itch pathway neurons. Neuropathic itch is a symptom …

Summary N 6-methyladenosine (m 6 A) affects multiple aspects of mRNA metabolism and
regulates developmental transitions by promoting mRNA decay. Little is known about the …

Alternative splicing (AS) is one crucial step of gene expression that must be tightly regulated
during neurodevelopment. However, the precise timing of developmental splicing switches …

We generated a knockout mouse for the neuronal-specific β-tubulin isoform Tubb3 to
investigate its role in nervous system formation and maintenance. Tubb3−/− mice have no …

Skeletal muscle atrophy occurs under various conditions, such as disuse, denervation,
fasting, aging, and various diseases. Although the underlying molecular mechanisms are …

The identification of drug targets is highly challenging, particularly for diseases of the brain.
To address this problem, we developed and experimentally validated a general …

The failure of axons to regenerate in the damaged mammalian CNS is the main impediment
to functional recovery. There are many molecules and structures in the environment of the …

In mammals, spinal cord injury (SCI) leads to dramatic losses in neurons and synaptic
connections, and consequently function. Unlike mammals, lampreys are vertebrates that …

Axonal regrowth is crucial for recovery from CNS injury but is severely restricted in adult
mammals. We used a genome-wide loss-of-function screen for factors limiting axonal …