Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies
Amplification of epidermal growth factor receptor (EGFR) and its active mutant EGFRvIII
occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in …
occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in …
EGFR as a clinical marker in glioblastomas and other gliomas
Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein and a member of
the tyrosine kinase superfamily receptor. Gliomas are tumors originating from glial cells …
the tyrosine kinase superfamily receptor. Gliomas are tumors originating from glial cells …
Multiplexed profiling of single extracellular vesicles
Extracellular vesicles (EV) are a family of cell-originating, membrane-enveloped
nanoparticles with diverse biological function, diagnostic potential, and therapeutic …
nanoparticles with diverse biological function, diagnostic potential, and therapeutic …
Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy
Outcomes of anticancer therapy vary dramatically among patients due to diverse genetic
and molecular backgrounds, highlighting extensive intertumoral heterogeneity. The …
and molecular backgrounds, highlighting extensive intertumoral heterogeneity. The …
Exosomes as a biomarker platform for detecting epidermal growth factor receptor–positive high-grade gliomas
SV Manda, Y Kataria, BR Tatireddy… - Journal of …, 2018 - thejns.org
OBJECTIVE High-grade glial brain tumors are often characterized by an elevated
expression of the tumorigenic epidermal growth factor receptor variant III (EGFRvIII). The …
expression of the tumorigenic epidermal growth factor receptor variant III (EGFRvIII). The …
Opposite interplay between the canonical WNT/β-catenin pathway and PPAR gamma: a potential therapeutic target in gliomas
A Vallée, Y Lecarpentier, R Guillevin, JN Vallée - Neuroscience bulletin, 2018 - Springer
In gliomas, the canonical Wingless/Int (WNT)/β-catenin pathway is increased while
peroxisome proliferator-activated receptor gamma (PPAR-γ) is downregulated. The two …
peroxisome proliferator-activated receptor gamma (PPAR-γ) is downregulated. The two …
Exploiting polypharmacology for improving therapeutic outcome of kinase inhibitors (KIs): An update of recent medicinal chemistry efforts
X Ma, X Lv, J Zhang - European Journal of Medicinal Chemistry, 2018 - Elsevier
Polypharmacology has been increasingly advocated for the therapeutic intervention in
complex pathological conditions, exemplified by cancer. Although kinase inhibitors (KIs) …
complex pathological conditions, exemplified by cancer. Although kinase inhibitors (KIs) …
The role of PI3K in Met driven cancer: a recap
A Hervieu, S Kermorgant - Frontiers in molecular biosciences, 2018 - frontiersin.org
The Receptor Tyrosine Kinase (RTK) Met, overexpressed or mutated in cancer, plays a
major role in cancer progression and represents an attractive target for cancer therapy …
major role in cancer progression and represents an attractive target for cancer therapy …
NQO1 is regulated by PTEN in glioblastoma, mediating cell proliferation and oxidative stress
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with a dismal prognosis,
and the patients carrying EGFR‐driven tumors with PTEN mutation do not respond to anti …
and the patients carrying EGFR‐driven tumors with PTEN mutation do not respond to anti …
Contemporary management of high-grade gliomas
High-grade gliomas, including glioblastoma, are the most common malignant brain tumors
in adults. Despite intensive efforts to develop new therapies for these diseases, treatment …
in adults. Despite intensive efforts to develop new therapies for these diseases, treatment …