Malaria parasite infection continues to inflict extensive morbidity and mortality in resource-
poor countries. The insufficiently understood parasite biology, continuously evolving drug …

Each year malaria kills hundreds of thousands of people and infects hundreds of millions of
people despite current control measures. An effective malaria vaccine will likely be …

Genetically attenuated malaria parasites (GAP) that arrest during liver stage development
are powerful immunogens and afford complete and durable protection against sporozoite …

Background: Although rigorous efforts have substantially decreased the malaria burden
through decades, it still threatens the lives of millions of children. Development of an …

In August 2017, the National Institute of Allergy and Infectious Diseases convened a
meeting, entitled “Understanding the Liver-Stage Biology of Malaria Parasites to Enable and …

Background Despite the importance of the Plasmodium berghei oocyst capsule protein
(PbCap380) in parasite survival, very little is known about the orthologous Plasmodium …

Background: Individuals living in malaria-endemic regions develop immunity against severe
malaria, but it is unclear whether immunity against pre-erythrocytic stages that blocks …

Protection against a malaria infection can be achieved by immunization with live-attenuated
Plasmodium sporozoites and while the precise mechanisms of protection remain unknown …

Malaria is a major concern for international health authorities. Millions of people contract it
every year in the world due to a parasite of the Plasmodium genus. Due to the complexity of …

In this study we created genetically attenuated rodent malaria parasites (GAPs) that express
putative immunomodulatory proteins to increase GAP immunogenicity. Four different …