Genetic architecture describes the characteristics of genetic variation that are responsible for
heritable phenotypic variability. It depends on the number of genetic variants affecting a trait …

For many years it has been known that high doses of long chain omega-3 fatty acids are
beneficial in the treatment of hypertriglyceridaemia. Over the last three decades, there has …

We apply integrative approaches to expression quantitative loci (eQTLs) from 44 tissues
from the Genotype-Tissue Expression project and genome-wide association study data …

Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers
potential advantages for locus discovery. We perform WGS in 16,324 participants from four …

Genome-wide association analysis advanced understanding of blood pressure (BP), a
major risk factor for vascular conditions such as coronary heart disease and stroke …

Plasma levels of HDL cholesterol (HDL-C) predict the risk of cardiovascular disease at the
epidemiological level, but a direct causal role for HDL in cardiovascular disease remains …

Disruption in the metabolism of lipids is broadly classified under dyslipidemia and relates to
the concentration of lipids in the blood. Dyslipidemia is a predictor of cardio-metabolic …

Vitamin E (VE) has a recognized leading role as a contributor to the protection of cell
constituents from oxidative damage. However, evidence suggests that the health benefits of …

The elucidation of the molecular basis of the rare disease, sitosterolemia, has revolutionized
our mechanistic understanding of how dietary sterols are excreted and how cholesterol is …

The genetic regulation and physiological impact of most lipid species are unexplored. Here,
we profiled 129 plasma lipid species across 49 strains of the BXD mouse genetic reference …