Addressing global ruminant agricultural challenges through understanding the rumen microbiome: past, present, and future
The rumen is a complex ecosystem composed of anaerobic bacteria, protozoa, fungi,
methanogenic archaea and phages. These microbes interact closely to breakdown plant …
methanogenic archaea and phages. These microbes interact closely to breakdown plant …
From correlation to causation: analysis of metabolomics data using systems biology approaches
Introduction Metabolomics is a well-established tool in systems biology, especially in the top–
down approach. Metabolomics experiments often results in discovery studies that provide …
down approach. Metabolomics experiments often results in discovery studies that provide …
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders,
including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD) …
including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD) …
Comprehensive functional genomic resource and integrative model for the human brain
INTRODUCTION Strong genetic associations have been found for a number of psychiatric
disorders. However, understanding the underlying molecular mechanisms remains …
disorders. However, understanding the underlying molecular mechanisms remains …
Co-regulatory networks of human serum proteins link genetics to disease
Proteins circulating in the blood are critical for age-related disease processes; however, the
serum proteome has remained largely unexplored. To this end, 4137 proteins covering most …
serum proteome has remained largely unexplored. To this end, 4137 proteins covering most …
Gene co-expression analysis for functional classification and gene–disease predictions
S Van Dam, U Vosa, A van der Graaf… - Briefings in …, 2018 - academic.oup.com
Gene co-expression networks can be used to associate genes of unknown function with
biological processes, to prioritize candidate disease genes or to discern transcriptional …
biological processes, to prioritize candidate disease genes or to discern transcriptional …
Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility
Here we use deep sequencing to identify sources of variation in mRNA splicing in the
dorsolateral prefrontal cortex (DLPFC) of 450 subjects from two aging cohorts. Hundreds of …
dorsolateral prefrontal cortex (DLPFC) of 450 subjects from two aging cohorts. Hundreds of …
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
MJ Gandal, JR Haney, NN Parikshak, V Leppa… - Science, 2018 - science.org
The predisposition to neuropsychiatric disease involves a complex, polygenic, and
pleiotropic genetic architecture. However, little is known about how genetic variants impart …
pleiotropic genetic architecture. However, little is known about how genetic variants impart …
The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease
Alzheimer's disease (AD) affects half the US population over the age of 85 and is universally
fatal following an average course of 10 years of progressive cognitive disability. Genetic and …
fatal following an average course of 10 years of progressive cognitive disability. Genetic and …
Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease
Background Disease-associated-microglia (DAM) represent transcriptionally-distinct and
neurodegeneration-specific microglial profiles with unclear significance in Alzheimer's …
neurodegeneration-specific microglial profiles with unclear significance in Alzheimer's …