Background: Cardiovascular disease (CVD), the most common cause of death globally,
accounts for~ 30% of all deaths worldwide. Hypertension is a common contributor to …

It is increasingly clear that inflammatory diseases and cancers are influenced by cleavage
products of the pro-hormone chromogranin A (CgA), such as the 21-amino acids long …

Summary Although CD8+ T-cell-mediated autoimmune β cell destruction occurs in type 1
diabetes (T1D), the target epitopes processed and presented by β cells are unknown. To …

Background We investigated whether a panel of 12 potential novel biomarkers consisting of
proteins involved in synapse functioning and immunity would be able to distinguish patients …

Scope The aim of this study was to develop and evaluate a parallel reaction monitoring
mass spectrometry (PRM‐MS) assay consisting of a panel of potential protein biomarkers in …

The molecular mechanisms underpinning susceptibility loci for type 2 diabetes (T2D) remain
poorly understood. Coding variants in peptidylglycine α-amidating monooxygenase (PAM) …

Neuropeptides are essential signaling molecules transported and secreted by dense‐core
vesicles (DCV s), but the number of DCV s available for secretion, their subcellular …

Sorting of soluble proteins for transport to intracellular compartments and for secretion from
cells is essential for cell and tissue homeostasis. The trans-Golgi network (TGN) is a major …

The nervous system of the free-living planktonic larvae of sea urchins is relatively “simple,”
but sufficiently complex to enable sensing of the environment and control of swimming and …

It is today widely accepted that several types of high molecular weight (MW)
neurotransmitters produced by neurons are synthesized at the cell body, selectively stored …