Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …

Senescent cells (SCs) arise from normal cells in multiple organs due to inflammatory,
metabolic, DNA damage, or tissue damage signals. SCs are non-proliferating but …

Cellular senescence is an irreversible growth arrest that occurs as a result of different
damaging stimuli, including DNA damage, telomere shortening and dysfunction or …

Skin cells are vulnerable to oxidative stress-induced senescence, which may lead to
abnormal aging or aging-related disorders. Therefore, strategies that can ameliorate …

Abstract Purpose of the Review Senescent cells have the capacity to both effect and limit
fibrosis. Senotherapeutics target senescent cells to improve aging conditions. Here, we …

Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective
induction of splicing factors HNRNPD and SRSF2 - PMC Back to Top Skip to main content NIH …

Background The oldest-old (subjects aged 90 years and older) population represents the
fastest growing segment of society and shows a high dementia prevalence rate of up to …

It remains unclear how exercise, as an entropic event, brings benefit against human aging.
Here we examined longitudinal changes of p16 Ink4a+ senescent cells in skeletal muscle of …

Oxidative stress has been involved in the aging process and the pathogenesis of type-2
diabetes, which is a serious health problem worldwide. This study investigates the anti …

Since Hayflick's discovery of cellular senescence (CS), a great volume of knowledge in the
field has been accumulated and intensively discussed. Here, we attempted to organize the …