Introduction Metabolomics is a well-established tool in systems biology, especially in the top–
down approach. Metabolomics experiments often results in discovery studies that provide …

Gene co-expression networks can be used to associate genes of unknown function with
biological processes, to prioritize candidate disease genes or to discern transcriptional …

We recently presented a three-pronged association study that integrated human intestinal
microbiome data derived from shotgun-based sequencing with untargeted serum …

Female fertility is a highly regulated process involving the synchronized activities of multiple
tissues. The underlying genomic regulation of the tissue synchronization is poorly …

Habitual aerobic exercise enhances physiological function and reduces risk of morbidity and
mortality throughout life, but the underlying molecular mechanisms are largely unknown …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that is influenced by
genetic and environmental risk factors, such as inheritance of ε4 allele of APOE (APOE4) …

Human speech is one of the few examples of vocal learning among mammals yet~ half of
avian species exhibit this ability. Its neurogenetic basis is largely unknown beyond a shared …

Cancer cachexia is a devastating, multifactorial, and irreversible syndrome characterized by
skeletal muscle reduction with or without fat loss. Although much attention has been focused …

Expression of human Apolipoprotein E (APOE) modulates the inflammatory response in an
isoform specific manner, with APOE4 isoform eliciting a stronger pro-inflammatory response …

The repertoire of miRNAs has considerably expanded during metazoan evolution, and
duplication is an important mechanism for generating new functional miRNAs. However …