Graves' disease is the most frequent cause of hyperthyroidism. Many questions remain
about the choice of diagnostic evaluations and treatment strategy according to clinical …

Clinical measurements can be viewed as useful intermediate phenotypes to promote
understanding of complex human diseases. To acquire comprehensive insights into the …

Understanding natural selection is crucial to unveiling evolution of modern humans. Here,
we report natural selection signatures in the Japanese population using 2234 high-depth …

Takayasu arteritis (TAK) is a systemic vasculitis with severe complications that affects the
aorta and its large branches. HLA-B* 52 is an established susceptibility locus to TAK. To …

Lung cancer has several genetic associations identified within the major histocompatibility
complex (MHC); although the basis for these associations remains elusive. Here, we …

Psoriasis vulgaris (PsV) is an autoimmune disease of skin and joints with heterogeneity in
epidemiologic and genetic landscapes of global populations. We conducted an initial …

MicroRNAs (miRNAs) modulate the post-transcriptional regulation of target genes and are
related to biology of complex human traits, but genetic landscape of miRNAs remains largely …

Crohn's disease (CD) and ulcerative colitis (UC) are the major types of chronic inflammatory
bowel disease (IBD) characterized by recurring episodes of inflammation of the …

Objective. Shared epitope (SE) alleles are the most significant genetic susceptibility locus in
rheumatoid arthritis (RA); however, their target populations in CD4+ T cells are not well …

Background The classical human leucocyte antigen (HLA) genes were the most important
genetic determinant for Graves' disease (GD). The aim of the study was to fine map causal …