[HTML][HTML] RNA interference as a prospective tool for the control of human viral infections
A Levanova, MM Poranen - Frontiers in Microbiology, 2018 - frontiersin.org
RNA interference (RNAi), which is mediated by small interfering RNAs (siRNAs) derived
from viral genome or its replicative intermediates, is a natural antiviral defense in plants …
from viral genome or its replicative intermediates, is a natural antiviral defense in plants …
Post-exposure treatments for Ebola and Marburg virus infections
RW Cross, CE Mire, H Feldmann… - Nature Reviews Drug …, 2018 - nature.com
The filoviruses—Ebola virus and Marburg virus—cause lethal haemorrhagic fever in
humans and non-human primates (NHPs). Filoviruses present a global health threat both as …
humans and non-human primates (NHPs). Filoviruses present a global health threat both as …
Analysis of CD8+ T cell response during the 2013–2016 Ebola epidemic in West Africa
S Sakabe, BM Sullivan, JN Hartnett… - Proceedings of the …, 2018 - National Acad Sciences
The recent Ebola epidemic exemplified the importance of understanding and controlling
emerging infections. Despite the importance of T cells in clearing virus during acute …
emerging infections. Despite the importance of T cells in clearing virus during acute …
Ebola virus disease: an update on post-exposure prophylaxis
WA Fischer, P Vetter, DG Bausch, T Burgess… - The Lancet Infectious …, 2018 - thelancet.com
The massive outbreak of Ebola virus disease in west Africa between 2013 and 2016
resulted in intense efforts to evaluate the efficacy of several specific countermeasures …
resulted in intense efforts to evaluate the efficacy of several specific countermeasures …
Ebola immunity: gaining a winning position in lightning chess
A Ploquin, Y Zhou, NJ Sullivan - The Journal of Immunology, 2018 - journals.aai.org
Zaire ebolavirus (EBOV), one of five species in the genus Ebolavirus, is the causative agent
of the hemorrhagic fever disease epidemic that claimed more than 11,000 lives from 2014 to …
of the hemorrhagic fever disease epidemic that claimed more than 11,000 lives from 2014 to …
Clinical manifestations and pathogenesis of uveitis in Ebola virus disease survivors
In the wake of the international Ebola virus disease (EVD) outbreak from 2014 to 2016,
thousands of EVD survivors are at-risk of ophthalmic manifestations, as well as systemic …
thousands of EVD survivors are at-risk of ophthalmic manifestations, as well as systemic …
Enhancement of Ebola virus infection by seminal amyloid fibrils
The 2014 western Africa Ebola virus (EBOV) epidemic was unprecedented in magnitude,
infecting over 28,000 and causing over 11,000 deaths. During this outbreak, multiple …
infecting over 28,000 and causing over 11,000 deaths. During this outbreak, multiple …
Treatment-focused Ebola trials, supportive care and future of filovirus care
M Keshtkar-Jahromi, KAO Martins… - Expert review of anti …, 2018 - Taylor & Francis
ABSTRACT Introduction: During the 2014–2016 Ebolavirus (EBOV) outbreak, several
candidate therapeutics were used in EBOV-infected patients in clinical trials and under …
candidate therapeutics were used in EBOV-infected patients in clinical trials and under …
[PDF][PDF] An international review of high level isolation units
A Sykes - 2018 - media.churchillfellowship.org
As the UK sees increasing cases of High Consequence Infectious Diseases (HCIDs) and the
national HCID programme expands, in response to an ever present threat of a significant …
national HCID programme expands, in response to an ever present threat of a significant …
[PDF][PDF] siRNA 药物研究进展
贺婉红， 薛嫚， 李芳， 俸灵林， 张婷 - 中国药学杂志, 2018 - journal11.magtechjournal.com
RNA 干扰技术(RNAi) 因其具有高效, 高特异性, 低毒等优点在生物医药领域方面潜力巨大,
为新药的研发提供了非常好的思路. 通过合理设计, 化学修饰及载体可在一定程度上解决小干扰 …
为新药的研发提供了非常好的思路. 通过合理设计, 化学修饰及载体可在一定程度上解决小干扰 …