The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

The Mayo Clinic recently introduced a diagnostic test that quantifies plasma ceramides in
order to identify patients at risk of major adverse cardiac events. By comparing recent …

Background & aims Non-alcoholic fatty liver disease (NAFLD) is a common liver disease in
Western countries. Metabolic disorders which are increasing in prevalence, such as …

Background The incidence of chronic disease is elevated in women after menopause.
Natural variation in muscle expression of the estrogen receptor (ER) α is inversely …

Sphingolipids are class of metabolically distinct lipids that play structural and signaling
functions in all organisms. Sphingolipid metabolism is deregulated during various diseases …

Adiponectin is known to play primary roles in the regulation of systemic glucose
homeostasis and lipid metabolism. Interestingly, emerging evidence indicates beneficial …

Lipotoxic cardiomyopathy (LCM) is characterized by abnormal myocardial accumulation of
lipids, including ceramide; however, the contribution of ceramide to the etiology of LCM is …

Ceramide accumulation in muscle and in liver is implicated in the induction of insulin
resistance. Much less in known about the role of ceramide in adipose tissue. The aim of the …

Nonalcoholic fatty liver disease (NAFLD) is a group of liver disorders encompassing simple
hepatic steatosis and its more aggressive forms of nonalcoholic steatohepatitis and …

Farber Disease (FD) is an ultra-rare Lysosomal Storage Disorder caused by deficient acid
ceramidase (ACDase) activity. Patients with ACDase deficiency manifest a spectrum of …