Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …

The worldwide emergence of New Delhi metallo-β-lactamase-1 (NDM-1) as a
carbapenemase able to hydrolyze nearly all available β-lactam antibiotics has characterized …

Drug-resistant superbugs pose a huge threat to human health. Infections by
Enterobacteriaceae producing metallo-β-lactamases (MBLs), eg, New Delhi metallo-β …

Antibiotic resistance caused by β-lactamase production continues to present a growing
challenge to the efficacy of β-lactams and their role as the most important class of clinically …

Methods: Antibacterial activity of the organic acid and their combinations was tested by disc
diffusion method against NDM-1 E. coli, and minimum inhibitory concentration (MIC) was …

New Delhi metallo-β-lactmase-1 (NDM-1) catalyzes the hydrolysis of β-lactam antibiotics
and cleaves the β-lactam ring of the molecule, conferring bacterial resistance against these …

Bacteria containing blaNDM-1 gene are a growing threat to almost all clinically β-lactam
antibiotics. Especially, the New Delhi metallo-β-lactamase (NDM-1) has become a potential …

Metallo-β-lactamases (MBLs) are a family of Zn (II)-dependent enzymes that can hydrolyze
almost all β-lactam antibiotics. Horizontal transfer of the genes encoding MBLs among Gram …

2010 年首次报道的新德里金属β-内酰胺酶(NDM-1) 能水解几乎所有β-内酰胺类抗生素,
产生NDM-1 的菌株被称为" 超级细菌". 由于缺乏有效的抗生素, 目前临床上还没有能够完全治愈 …

The efficiency of bacteria in acquiring resistance for their survival ensures a never-ending
war against resistance. The only tactic to curtail the resistance crisis is to keep pace with it …