Abstract p53 is a transcription factor that suppresses tumor growth through regulation of
dozens of target genes with diverse biological functions. The activity of this master …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Autophagy is an indispensable mechanism of the eukaryotic cell, facilitating the removal and
renewal of cellular components and thereby balancing the cell's energy consumption and …

Plant immunity depends on massive expression of pathogenesis-related genes (PRs)
whose transcription is de-repressed by pathogen-induced signals. Salicylic acid (SA) acts as …

Previously, we designed and synthesized a series of o-aminobenzamide-based histone
deacetylase (HDAC) inhibitors, among which the representative compound 11a exhibited …

Tumor development and progression is the consequence of genetic as well as epigenetic
alterations of the cell. As part of the epigenetic regulatory system, histone acetyltransferases …

Glioblastoma is one of the most aggressive forms of cancers and has a poor prognosis.
Genomewide analyses have revealed that a set of core signaling pathways, the p53, RB …

Purpose The aim of this study is to investigate the inhibition of cancer growth by
pterostilbene through Metastasis-Associated Protein 1 (MTA1) and the histone deacetylase …

The genes encoding MDM2 and CDK4 are frequently co-amplified in sarcomas, and
inhibitors to both targets are approved or clinically tested for therapy. However, we show that …

The general control nonrepressed protein 5 (GCN5) plays a crucial role in many biological
processes. Dysregulation of GCN5 has been closely related to various human diseases …