The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

The adult quiescent blood–brain barrier (BBB), a structure organised by endothelial cells
through interactions with pericytes, astrocytes, neurons and microglia in the neurovascular …

Brain fluids are rigidly regulated to provide stable environments for neuronal function, eg,
low K+, Ca 2+, and protein to optimise signalling and minimise neurotoxicity. At the same …

The blood coagulation protein fibrinogen is deposited in the brain in a wide range of
neurological diseases and traumatic injuries with blood–brain barrier (BBB) disruption …

Background Receptor-mediated transcytosis is one of the major routes for drug delivery of
large molecules into the brain. The aim of this study was to develop a novel model of the …

Blood–brain barrier pathology is recognised as a central factor in the development of many
neurological disorders, but much less is known about the role of the blood–brain barrier in …

The endothelial barrier consists of intercellular contacts localized in the cleft between
endothelial cells, which is covered by the glycocalyx in a sievelike manner. Both types of …

Vascular disruption is the underlying cause of cerebral hemorrhage, including intracerebral,
subarachnoid and intraventricular hemorrhage. The disease etiology also involves cerebral …

The blood–brain barrier (BBB) is the principal regulator of transport of molecules and cells
into and out of the central nervous system (CNS). It comprises endothelial cells, pericytes …

Claudin-5 is a tight junction (TJ) protein in the blood-brain barrier (BBB) that has recently
attracted increased attention. Numerous studies have demonstrated that claudin-5 regulates …