A perspective on the evolving story of PSMA biology, PSMA-based imaging, and endoradiotherapeutic strategies

DS O'Keefe, DJ Bacich, SS Huang… - Journal of Nuclear …, 2018 - Soc Nuclear Med
In this review, we cover the evolution of knowledge on the biology of prostate-specific
membrane antigen (PSMA) and its translation to therapy. The usual key to discovery is a …

[HTML][HTML] Current status of theranostics in prostate cancer

I Virgolini, C Decristoforo, A Haug, S Fanti… - European journal of …, 2018 - Springer
The aim of this review is to report on the current status of prostate-specific membrane
antigen (PSMA)-directed theranostics in prostate cancer (PC) patients. The value of 68 Ga …

[HTML][HTML] Expression of prostate-specific membrane antigen (PSMA) on biopsies is an independent risk stratifier of prostate cancer patients at time of initial diagnosis

MC Hupe, C Philippi, D Roth, C Kümpers… - Frontiers in …, 2018 - frontiersin.org
Background: Stratifying prostate cancer (PCa) patients into risk groups at time of initial
diagnosis enabling a risk-adapted disease management is still a major clinical challenge …

Imaging of nonprostate cancers using PSMA-targeted radiotracers: rationale, current state of the field, and a call to arms

RAS Fragomeni, T Amir, S Sheikhbahaei… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA) is a type II transmembrane glycoprotein that is
highly overexpressed on prostate cancer epithelial cells and for which there is a growing …

[HTML][HTML] The expansion of targetable biomarkers for CAR T cell therapy

MH Townsend, G Shrestha, RA Robison… - Journal of Experimental & …, 2018 - Springer
Biomarkers are an integral part of cancer management due to their use in risk assessment,
screening, differential diagnosis, prognosis, prediction of response to treatment, and …

[HTML][HTML] New prostate cancer targets for diagnosis, imaging, and therapy: focus on prostate-specific membrane antigen

A Cimadamore, M Cheng, M Santoni… - Frontiers in …, 2018 - frontiersin.org
The rising incidence rate of the cancer in the prostate gland has increased the demand for
improved diagnostic, imaging, and therapeutic approaches. Prostate-specific membrane …

Physiologic distribution of PSMA-ligand in salivary glands and seromucous glands of the head and neck on PET/CT

TJWK Nulent, MH Valstar, B de Keizer… - Oral surgery, oral …, 2018 - Elsevier
Objectives Prostate-specific membrane antigen (PSMA) positron emission
tomography/computed tomography (PET/CT) is used for detection and (re) staging of …

[HTML][HTML] Neovascular PSMA expression is a common feature in malignant neoplasms of the thyroid

B Heitkötter, K Steinestel, M Trautmann, I Grünewald… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Aim PSMA (prostate-specific membrane antigen) is physiologically expressed in normal
prostate tissue and over expressed in prostate cancer cells, therefore constituting a potential …

Targeting of folate-conjugated liposomes with co-entrapped drugs to prostate cancer cells via prostate-specific membrane antigen (PSMA)

Y Patil, H Shmeeda, Y Amitay, P Ohana… - … , Biology and Medicine, 2018 - Elsevier
Folate-targeted liposomes (FTL) were tested as drug delivery vehicles to PSMA-positive
cancer cells. We used FL with co-entrapped mitomycin C lipophilic prodrug (MLP) and …

Methods for controlling T cell proliferation

D Spencer, AE Foster, K Slawin - US Patent 9,944,690, 2018 - Google Patents
T cells express receptors on their surfaces (ie, T cell receptors) that recognize antigens
presented on the surface of antigen-presenting cells. During a normal immune response …