Adjuvanted influenza vaccines

JS Tregoning, RF Russell, E Kinnear - Human vaccines & …, 2018 - Taylor & Francis
In spite of current influenza vaccines being immunogenic, evolution of the influenza virus
can reduce efficacy and so influenza remains a major threat to public health. One approach …

[HTML][HTML] Induction of interleukin-10 producing dendritic cells as a tool to suppress allergen-specific T helper 2 responses

S Schülke - Frontiers in immunology, 2018 - frontiersin.org
Dendritic cells (DCs) are gatekeepers of the immune system that control induction and
polarization of primary, antigen-specific immune responses. Depending on their …

[HTML][HTML] Prevention efforts for malaria

TA Tizifa, AN Kabaghe, RS McCann… - … tropical medicine reports, 2018 - Springer
Abstract Purpose of Review Malaria remains a global burden contributing to morbidity and
mortality especially in children under 5 years of age. Despite the progress achieved towards …

Controlled human malaria infection: applications, advances, and challenges

DI Stanisic, JS McCarthy, MF Good - Infection and immunity, 2018 - Am Soc Microbiol
Controlled human malaria infection (CHMI) entails deliberate infection with malaria
parasites either by mosquito bite or by direct injection of sporozoites or parasitized …

The roles of resident, central and effector memory CD 4 T‐cells in protective immunity following infection or vaccination

JI Gray, LM Westerhof, MKL MacLeod - Immunology, 2018 - Wiley Online Library
Immunological memory provides rapid protection to pathogens previously encountered
through infection or vaccination. CD 4 T‐cells play a central role in all adaptive immune …

[HTML][HTML] Spatio-temporal analysis of Plasmodium falciparum prevalence to understand the past and chart the future of malaria control in Kenya

PM Macharia, E Giorgi, AM Noor, E Waqo, R Kiptui… - Malaria journal, 2018 - Springer
Background Spatial and temporal malaria risk maps are essential tools to monitor the impact
of control, evaluate priority areas to reorient intervention approaches and investments in …

Prime and target immunization protects against liver-stage malaria in mice

A Gola, D Silman, AA Walters, S Sridhar… - Science translational …, 2018 - science.org
Despite recent advances in treatment and vector control, malaria is still a leading cause of
death, emphasizing the need for an effective vaccine. The malaria life cycle can be …

Virus‐like particle engineering: from rational design to versatile applications

X Ding, D Liu, G Booth, W Gao, Y Lu - Biotechnology Journal, 2018 - Wiley Online Library
As mimicking natural virus structures, virus‐like particles (VLPs) have evolved to become a
widely accepted technology used for humans which are safe, highly efficacious, and …

[HTML][HTML] Pyrethroid insecticides maintain repellent effect on knock-down resistant populations of Aedes aegypti mosquitoes

NM Bowman, K Akialis, G Cave, R Barrera… - PLoS …, 2018 - journals.plos.org
Pyrethroid-treated clothing is commonly worn for protection against mosquitoes; pyrethroids
are both insecticides and repellents. Pyrethroid resistance has become increasingly …

Cryo-EM structure of P. falciparum circumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts

D Oyen, JL Torres, CA Cottrell, C Richter King… - Science …, 2018 - science.org
The circumsporozoite protein (CSP) on the surface of Plasmodium falciparum sporozoites is
important for parasite development, motility, and host hepatocyte invasion. However …