The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

Importance Stroke is the second leading cause of death in the world, and nearly one-third of
ischemic strokes are lacunar strokes (LSs) or small subcortical infarcts. Although smaller in …

White matter hyperintensities (WMH) are frequently divided into periventricular (PWMH) and
deep (DWMH), and the two classes have been associated with different cognitive …

Importance Identifying asymptomatic individuals at high risk of impending cognitive decline
because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk …

Dementia is a major social and economic problem for our aging population. One of the most
common of dementia in the elderly is cerebral small vessel disease (SVD). Magnetic …

Background: White matter hyperintensities (WMHs) are related to cognitive dysfunction in
the general population. The clinical relevance of WMHs in patients with Alzheimer's disease …

Subcortical small-vessel disease (SSVD) is a disorder well characterized from the clinical,
imaging, and neuropathological viewpoints. SSVD is considered the most prevalent …

Background and Purpose—Cerebral small-vessel disease is a major cause of cognitive
impairment. Perivascular spaces (PvS) occur in small-vessel disease, but their relationship …

OBJECTIVE Structural brain abnormalities are key risk factors for brain diseases, such as
dementia, stroke, and depression, in type 2 diabetes. It is unknown whether structural brain …

Abstract Purpose of Review We reviewed the most recent literature examining the
associations between the Mediterranean-style diet (MD), neurodegenerative diseases, and …