S-palmitoylation (S-PALM) is a lipid modification that involves the linkage of a fatty acid
chain to cysteine residues of the substrate protein. This common posttranslational …

The majority of neuronal proteins involved in cellular signaling undergo different
posttranslational modifications significantly affecting their functions. One of these …

It is well-documented that serotonin (5-HT) exerts its pharmacological effects through a
series of 5-HT receptors. The most recently identified member of this family, 5-HT7, was first …

Serotonin 5-HT7 receptor (5-HT7R) has been the subject of intense research efforts
because of its presence in brain areas such as the hippocampus, hypothalamus, and cortex …

A computational approach combining a structure–activity relationship library of halogenated
and the corresponding unsubstituted ligands (called XSAR) with QM-based molecular …

How GPCRs and G proteins interact is important for their biologic functions and their
functions as pharmacologic targets. It is still an open question whether receptors and G …

The allosteric regulation of G protein-coupled receptors (GPCRs) is a well-known
phenomenon, but there are only a few examples of allosteric modulation within the …

Summary Aims The serotonin 7 receptor (5‐HT 7R) subtype, coded by Htr7 gene, is broadly
expressed in the central nervous system (CNS) with clear involvement in behavioral …

Backgrounds Glioma is the most fatal primary brain glioma in central nervous system mainly
attributed to its high invasion. Prucalopride, a Serotonin-4 (5-HT4) receptor agonist, has …

Activation of 5-HT 7 receptors influences memory as well as circadian rhythms and other
processes. This study investigated the regulation of the 5-HT 7 receptors in the …