High-sensitivity troponin in the evaluation of patients with suspected acute coronary syndrome: a stepped-wedge, cluster-randomised controlled trial

ASV Shah, A Anand, FE Strachan, AV Ferry, KK Lee… - The Lancet, 2018 - thelancet.com
Background High-sensitivity cardiac troponin assays permit use of lower thresholds for the
diagnosis of myocardial infarction, but whether this improves clinical outcomes is unknown …

Targeting non-coding RNA in vascular biology and disease

J Hung, V Miscianinov, JC Sluimer, DE Newby… - Frontiers in …, 2018 - frontiersin.org
Only recently have we begun to appreciate the importance and complexity of the non-coding
genome, owing in some part to truly significant advances in genomic technology such as …

Cardiac Troponin-diagnostic problems and impact on cardiovascular disease

B Alaour, F Liew, TE Kaier - Annals of medicine, 2018 - Taylor & Francis
The definition of a high-sensitivity cardiac Troponin (cTn) assay describes the ability to
quantify a cardiac biomarker level in at least 50% of healthy individuals. This advance in …

Comparison between high-sensitivity cardiac troponin T and cardiac troponin I in a large general population cohort

P Welsh, D Preiss, ASV Shah, D McAllister… - Clinical …, 2018 - academic.oup.com
BACKGROUND Few data compare cardiac troponin T (cTnT) and cardiac troponin I (cTnI) in
a general population. We sought to evaluate the distribution and association between cTnT …

High-sensitivity cardiac troponin I and clinical risk scores in patients with suspected acute coronary syndrome

AR Chapman, K Hesse, J Andrews, K Ken Lee… - Circulation, 2018 - Am Heart Assoc
Background: High-sensitivity cardiac troponin assays can help to identify patients who are at
low risk of myocardial infarction in the emergency department. We aimed to determine …

Combining high-sensitivity cardiac troponin I and cardiac troponin T in the early diagnosis of acute myocardial infarction

N van der Linden, K Wildi, R Twerenbold… - Circulation, 2018 - Am Heart Assoc
Background: Combining 2 signals of cardiomyocyte injury, cardiac troponin I (cTnI) and T
(cTnT), might overcome some individual pathophysiological and analytical limitations and …

Validity of a novel point-of-care troponin assay for single-test rule-out of acute myocardial infarction

JW Pickering, JM Young, PM George… - JAMA …, 2018 - jamanetwork.com
Importance Emergency department (ED) investigations of patients with suspected acute
myocardial infarction (AMI) are time consuming, partly because of the turnaround time of …

Cardiac troponin I and cardiovascular risk in patients with chronic obstructive pulmonary disease

PD Adamson, JA Anderson, RD Brook… - Journal of the American …, 2018 - jacc.org
Background: Patients with chronic obstructive pulmonary disease (COPD) have increased
risk of cardiovascular events. Objectives: This study evaluated the association between high …

Evaluating rapid rule-out of acute myocardial infarction using a high-sensitivity cardiac troponin I assay at presentation

J Greenslade, E Cho, C Van Hise, T Hawkins… - Clinical …, 2018 - academic.oup.com
BACKGROUND Low concentrations of cardiac troponin (cTn) have been recommended for
rapid rule-out of acute myocardial infarction (AMI). We examined the Beckman Coulter …

Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at …

PA Kavsak, JT Neumann, L Cullen, M Than, C Shortt… - CMAJ, 2018 - Can Med Assoc
BACKGROUND: Testing for high-sensitivity cardiac troponin (hs-cTn) may assist triage and
clinical decision-making in patients presenting to the emergency department with symptoms …