When James Parkinson described the classical symptoms of the disease he could hardly
foresee the evolution of our understanding over the next two hundred years. Nowadays …

Despite enormous advances in our current understanding of PD since James Parkinson
described the “shaking palsy” 200 years ago, l‐dopa, in clinical use since the 1960s …

Objective To investigate whether REM sleep behavior disorder (RBD) is associated with
worse motor and cognitive decline in Parkinson disease (PD) Methods Four-hundred twenty …

Tremor is a commonly observed symptom in patients of Parkinson's disease (PD), and
accurate measurement of tremor severity is essential in prescribing appropriate treatment to …

Introduction The causes of pain in early/moderate Parkinson's disease (PD) are not well
understood. Although peripheral factors such as rigidity, reduced joint movements and poor …

Patients with Parkinson's disease experience disabling non-motor symptoms, including
autonomic dysfunction, cognitive decline, and sleep disorders. Pharmacologic treatments for …

Parkinson's disease patients report disturbed sleep patterns long before motor dysfunction.
Here, in parkin and pink1 models, we identify circadian rhythm and sleep pattern defects …

Pain is one of the most common and troublesome non‐motor symptoms of Parkinson's
disease (PD). It can appear at any time during the disease and is often present before …

Although Parkinson's disease (PD) is usually considered as a movement disorder, it is
strongly associated with non-motor symptoms (NMS), including smell and taste dysfunctions …

Tremor is one of the most visible features of Parkinson's disease (PD), and the majority of
PD patients experience tremor during the course of the disease. However, the distress …