Mineral bone disorders in chronic kidney disease

YC Hou, CL Lu, KC Lu - Nephrology, 2018 - Wiley Online Library
As the GFR loss aggravates, the disturbed mineral metabolism worsens the bone
microstructure and remodelling‐scenario, which is known as CKD‐mineral bone disease …

[HTML][HTML] Potential role for osteocalcin in the development of atherosclerosis and blood vessel disease

A Tacey, T Qaradakhi, T Brennan-Speranza, A Hayes… - Nutrients, 2018 - mdpi.com
There is increasing evidence for the involvement of the skeleton in the regulation of
atherosclerotic vascular disease. Osteocalcin, an osteoblast derived protein, exists in two …

[HTML][HTML] SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling

J Voelkl, TTD Luong, R Tuffaha… - The Journal of …, 2018 - Am Soc Clin Investig
Medial vascular calcification, associated with enhanced mortality in chronic kidney disease
(CKD), is fostered by osteo-/chondrogenic transdifferentiation of vascular smooth muscle …

Etidronate for prevention of ectopic mineralization in patients with pseudoxanthoma elasticum

G Kranenburg, PA de Jong, JW Bartstra… - Journal of the American …, 2018 - jacc.org
Background: In pseudoxanthoma elasticum (PXE), low pyrophosphate levels may cause
ectopic mineralization, leading to skin changes, visual impairment, and peripheral arterial …

Defective interplay between mTORC1 activity and endoplasmic reticulum stress-unfolded protein response in uremic vascular calcification

DK Panda, X Bai, Y Sabbagh… - American Journal …, 2018 - journals.physiology.org
Vascular calcification increases the risk of cardiovascular disease and death in patients with
chronic kidney disease (CKD). Increased activity of mammalian target of rapamycin complex …

The impact of osteocalcin, osteoprotegerin and osteopontin on arterial stiffness in chronic renal failure patients on hemodialysis

B Csiky, B Sági, A Peti, O Lakatos, V Prémusz… - Kidney and Blood …, 2018 - karger.com
Abstract Background/Aims: This cross-sectional study was designed to assess the
relationship between vascular stiffness (VS) and bone-related proteins involved in the …

Parathyroid hormone promotes osteoblastic differentiation of endothelial cells via the extracellular signal‑regulated protein kinase 1/2 and nuclear factor‑κB signaling …

ZY Cheng, T Ye, QY Ling, T Wu… - Experimental and …, 2018 - spandidos-publications.com
Vascular calcification (VC) occurs in patients with chronic kidney disease (CKD) and
contributes to cardiovascular dysfunction and mortality. Parathyroid hormone (PTH) is a …

[HTML][HTML] Bone markers and cardiovascular risk in type 2 diabetes patients

SR Zwakenberg, YT van der Schouw… - Cardiovascular …, 2018 - Springer
Background Vascular calcifications are associated with a three-to fourfold increased risk of
cardiovascular disease (CVD) and are highly prevalent in type 2 diabetes patients …

Microcalcifications, their genesis, growth, and biomechanical stability in fibrous cap rupture

L Cardoso, S Weinbaum - Molecular, Cellular, and Tissue Engineering of …, 2018 - Springer
For many decades, cardiovascular calcification has been considered as a passive process,
accompanying atheroma progression, correlated with plaque burden, and apparently …

Bone morphogenetic proteins 2/4 are upregulated during the early development of vascular calcification in chronic kidney disease

X Wei, W Wu, L Li, J Lin, Q Liu, L Gan… - BioMed research …, 2018 - Wiley Online Library
Vascular calcification is a main cause of increased cardiovascular morbidity and mortality in
chronic kidney disease (CKD) patients. This study aimed to investigate the role of the bone …