Brain, blood, cerebrospinal fluid, and serum biomarkers in schizophrenia

A Mohammadi, E Rashidi, VG Amooeian - Psychiatry research, 2018 - Elsevier
Over the last decade, finding a reliable biomarker for the early detection of schizophrenia
(Scz) has been a topic of interest. The main goal of the current review is to provide a …

[HTML][HTML] Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia

C Greene, J Kealy, MM Humphries, Y Gong, J Hou… - Molecular …, 2018 - nature.com
Schizophrenia is a neurodevelopmental disorder that affects up to 1% of the general
population. Various genes show associations with schizophrenia and a very weak nominal …

Unique molecular regulation of higher-order prefrontal cortical circuits: insights into the neurobiology of schizophrenia

D Datta, AFT Arnsten - ACS chemical neuroscience, 2018 - ACS Publications
Schizophrenia is associated with core deficits in cognitive abilities and impaired functioning
of the newly evolved prefrontal association cortex (PFC). In particular, neuropathological …

Efficacy and safety of brexpiprazole for the treatment of acute schizophrenia in Japan: A 6‐week, randomized, double‐blind, placebo‐controlled study

J Ishigooka, S Iwashita, Y Tadori - Psychiatry and clinical …, 2018 - Wiley Online Library
Aim This study aimed to evaluate the efficacy, safety, and tolerability of brexpiprazole
compared to placebo in Japanese patients with acute schizophrenia (SCZ). Methods We …

Syncytin-1, an endogenous retroviral protein, triggers the activation of CRP via TLR3 signal cascade in glial cells

X Wang, Z Liu, P Wang, S Li, J Zeng, X Tu… - Brain, Behavior, and …, 2018 - Elsevier
Schizophrenia is a devastating psychiatric disorder that impacts on social functioning and
quality of life, and there is accumulating evidence that inflammation is a potential pathogenic …

Nanosensors for the chemical imaging of acetylcholine using magnetic resonance imaging

Y Luo, EH Kim, CA Flask, HA Clark - ACS nano, 2018 - ACS Publications
A suite of imaging tools for detecting specific chemicals in the central nervous system could
accelerate the understanding of neural signaling events critical to brain function and …

Doxycycline prevents and reverses schizophrenic-like behaviors induced by ketamine in mice via modulation of oxidative, nitrergic and cholinergic pathways

B Ben-Azu, IA Omogbiya, AO Aderibigbe… - Brain Research …, 2018 - Elsevier
The involvement of oxidative, nitrergic, cholinergic and inflammatory alterations have been
reported to contribute to the pathophysiology of schizophrenia, a debilitating …

Schizophrenia: an overview

FH Farah - Asian Journal of Pharmaceutics (AJP), 2018 - asiapharmaceutics.info
Schizophrenia is still one of the most mysterious mental disorders that are characterized by
delusions, hallucinations, and impaired social behavior. Symptoms of schizophrenia emerge …

Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain‐Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress …

MK Seo, YH Kim, RS McIntyre, RB Mansur… - Neural …, 2018 - Wiley Online Library
Recent studies have shown that antipsychotic drugs have epigenetic effects. However, the
effects of antipsychotic drugs on histone modification remain unclear. Therefore, we …

[HTML][HTML] GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation

DY Jiang, Z Wu, CT Forsyth, Y Hu, SP Yee, G Chen - Molecular Brain, 2018 - Springer
Schizophrenia (SCZ) is a severe mental disorder characterized by delusion, hallucination,
and cognitive deficits. We have previously identified from schizophrenia patients a loss-of …