DNA methylation-based biomarkers and the epigenetic clock theory of ageing
S Horvath, K Raj - Nature reviews genetics, 2018 - nature.com
Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
Hazardous effects of chemical pesticides on human health–Cancer and other associated disorders
Poisoning from pesticides is a global public health problem and accounts for nearly 300,000
deaths worldwide every year. Exposure to pesticides is inevitable; there are different modes …
deaths worldwide every year. Exposure to pesticides is inevitable; there are different modes …
[HTML][HTML] An epigenetic biomarker of aging for lifespan and healthspan
Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …
generation of epigenetic biomarkers of aging were developed using chronological age as a …
The continuum of aging and age-related diseases: common mechanisms but different rates
Geroscience, the new interdisciplinary field that aims to understand the relationship between
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …
DNA methylation clocks in aging: categories, causes, and consequences
Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …
thought to promote diseases of aging, such as cancer. Recent studies have identified …
[HTML][HTML] Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies
DNA methylation (DNAm)-based biomarkers of aging have been developed for many
tissues and organs. However, these biomarkers have sub-optimal accuracy in fibroblasts …
tissues and organs. However, these biomarkers have sub-optimal accuracy in fibroblasts …
[HTML][HTML] Vaccination in the elderly: the challenge of immune changes with aging
The unprecedented increase of life expectancy challenges society to protect the elderly from
morbidity and mortality making vaccination a crucial mean to safeguard this population …
morbidity and mortality making vaccination a crucial mean to safeguard this population …
Brain age predicts mortality
Age-associated disease and disability are placing a growing burden on society. However,
ageing does not affect people uniformly. Hence, markers of the underlying biological ageing …
ageing does not affect people uniformly. Hence, markers of the underlying biological ageing …
A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: a cohort study
Background A person's rate of aging has important implications for his/her risk of death and
disease; thus, quantifying aging using observable characteristics has important applications …
disease; thus, quantifying aging using observable characteristics has important applications …
Eleven telomere, epigenetic clock, and biomarker-composite quantifications of biological aging: do they measure the same thing?
The geroscience hypothesis posits that therapies to slow biological processes of aging can
prevent disease and extend healthy years of life. To test such “geroprotective” therapies in …
prevent disease and extend healthy years of life. To test such “geroprotective” therapies in …