The sirtuin family of nicotinamide adenine dinucleotide–dependent deacylases (SIRT1–7)
are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …

The NAD+-dependent protein lysine deacylases of the Sirtuin family regulate various
physiological functions, from energy metabolism to stress responses. The human Sirtuin …

The nucleolus is a prominent membraneless organelle residing within the nucleus. The
nucleolus has been regarded as a housekeeping structure mainly known for its role in …

While the vast majority of cellular DNA in eukaryotes is contained in long linear strands in
chromosomes, we have long recognized some exceptions like mitochondrial DNA, plasmids …

The African turquoise killifish has recently gained significant traction as a new research
organism in the aging field. Our understanding of aging has strongly benefited from …

It has been nearly three decades since the budding yeast Saccharomyces cerevisiae
became a significant model organism for aging research and it has emerged as both simple …

Transcription of protein coding genes is accompanied by recruitment of COMPASS to
promoter-proximal chromatin, which methylates histone H3 lysine 4 (H3K4) to form …

Ribosome biogenesis is a complex and highly energy-demanding process that requires the
concerted action of all three nuclear RNA polymerases (Pol I–III) in eukaryotes. The three …

As average life span and elderly people prevalence in the western world population is
gradually increasing, the incidence of age-related diseases such as cancer, heart diseases …

Ribosomal RNA gene repeats (rDNA) encode ribosomal RNA, a major component of
ribosomes. Ribosome biogenesis is central to cellular metabolic regulation, and several …