[PDF][PDF] DNA methylation clocks in aging: categories, causes, and consequences
Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …
thought to promote diseases of aging, such as cancer. Recent studies have identified …
[HTML][HTML] A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup
JN Justice, L Ferrucci, AB Newman, VR Aroda… - Geroscience, 2018 - Springer
Recent advances indicate that biological aging is a potentially modifiable driver of late-life
function and chronic disease and have led to the development of geroscience-guided …
function and chronic disease and have led to the development of geroscience-guided …
[HTML][HTML] Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies
DNA methylation (DNAm)-based biomarkers of aging have been developed for many
tissues and organs. However, these biomarkers have sub-optimal accuracy in fibroblasts …
tissues and organs. However, these biomarkers have sub-optimal accuracy in fibroblasts …
[HTML][HTML] A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: a cohort study
Background A person's rate of aging has important implications for his/her risk of death and
disease; thus, quantifying aging using observable characteristics has important applications …
disease; thus, quantifying aging using observable characteristics has important applications …
Time and the metrics of aging
Ferrucci et al Time and the Metrics of Aging 741 disease, and all-cause mortality, although
the causal nature of these associations and whether telomere shortening affects the aging …
the causal nature of these associations and whether telomere shortening affects the aging …
A whole lifespan mouse multi-tissue DNA methylation clock
Age predictors based on DNA methylation levels at a small set of CpG sites, DNAm clocks,
have been developed for humans and extended to several other species. Three currently …
have been developed for humans and extended to several other species. Three currently …
[HTML][HTML] Polyamine metabolism and gene methylation in conjunction with one-carbon metabolism
K Soda - International journal of molecular sciences, 2018 - mdpi.com
Recent investigations have revealed that changes in DNA methylation status play an
important role in aging-associated pathologies and lifespan. The methylation of DNA is …
important role in aging-associated pathologies and lifespan. The methylation of DNA is …
Human microbiome aging clocks based on deep learning and tandem of permutation feature importance and accumulated local effects
Graphical Abstract Abstract The human gut microbiome is a complex ecosystem that both
affects and is affected by its host status. Previous analyses of gut microflora revealed …
affects and is affected by its host status. Previous analyses of gut microflora revealed …
Age and periodontal health—immunological view
JL Ebersole, DA Dawson, P Emecen Huja… - Current oral health …, 2018 - Springer
Abstract Purpose of the Review Aging clearly impacts a wide array of systems, in particular
the breadth of the immune system leading to immunosenescence, altered immunoactivation …
the breadth of the immune system leading to immunosenescence, altered immunoactivation …
Epigenetic age-predictor for mice based on three CpG sites
Y Han, M Eipel, J Franzen, V Sakk… - Elife, 2018 - elifesciences.org
Epigenetic clocks for mice were generated based on deep-sequencing analysis of the
methylome. Here, we demonstrate that site-specific analysis of DNA methylation levels by …
methylome. Here, we demonstrate that site-specific analysis of DNA methylation levels by …