Natural killer cell specificity for viral infections

Q Hammer, T Rückert, C Romagnani - Nature immunology, 2018 - nature.com
Natural killer (NK) cells are lymphocytes that contribute to the early immune responses to
viruses. NK cells are innate immune cells that do not express rearranged antigen receptors …

Diversification of human NK cells: Lessons from deep profiling

AJ Wilk, CA Blish - Journal of leukocyte biology, 2018 - academic.oup.com
NK cells are innate lymphocytes with important roles in immunoregulation,
immunosurveillance, and cytokine production. Originally defined on the functional basis of …

Inhibitory killer cell immunoglobulin-like receptors strengthen CD8+ T cell–mediated control of HIV-1, HCV, and HTLV-1

L Boelen, B Debebe, M Silveira, A Salam… - Science …, 2018 - science.org
Killer cell immunoglobulin-like receptors (KIRs) are expressed predominantly on natural
killer cells, where they play a key role in the regulation of innate immune responses. Recent …

Human natural killer receptors, co‐receptors, and their ligands

R Biassoni, MS Malnati - Current protocols in immunology, 2018 - Wiley Online Library
In the last 20 years, the study of human natural killer (NK) cells has moved from the first
molecular characterizations of very few receptor molecules to the identification of a plethora …

KIR3DL1 alleles and their epistatic interactions with human leukocyte antigen class I influence resistance and susceptibility to HIV-1 acquisition in the Pumwani sex …

M Luo, C Czarnecki, M Nebroski, J Kimani, N Bernard… - AIDS, 2018 - journals.lww.com
Objective: To determine the associations of KIR3DL1/S1 (3DL1/S1) and its epistatic
interactions with human leukocyte antigen class I (HLA-I) alleles with resistance and …

Diversification of Bw4 Specificity and Recognition of a Nonclassical MHC Class I Molecule Implicated in Maternal–Fetal Tolerance by Killer Cell Ig-like Receptors of …

P Banerjee, M Ries, SK Janaka… - The Journal of …, 2018 - journals.aai.org
The rhesus macaque is an important animal model for AIDS and other infectious diseases;
however, studies to address NK cell function in this species have been limited by the lack of …

impact of the Variable Killer ig-like receptor–human leukocyte antigen interactions on natural Killer cell cytotoxicity Toward Foreign cD4 T cells

J Hens, O Goovaerts, A Ceulemans, W Jennes… - Frontiers in …, 2018 - frontiersin.org
Background Natural killer (NK) cells are known to mount a response against foreign target
cells, where the absence of the dominant inhibitory killer Ig-like receptor (KIR)–human …

Natural killer cell responses to influenza A virus in the human lung

GE Cooper - 2018 - eprints.soton.ac.uk
Influenza infection is a major contributor to global mortality and morbidity, with high potential
for pandemic and vaccine evasion. Natural Killer (NK) cells are innate anti-viral effector cells …