Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a catalytic
component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to …

The GATA family of transcription factors is of crucial importance during embryonic
development, playing complex and widespread roles in cell fate decisions and tissue …

Summary Enhancer of Zeste 2 (EZH2) is the enzymatic subunit of Polycomb Repressive
Complex 2 (PRC2), which catalyzes histone H3 lysine 27 trimethylation (H3K27me3) at …

Polycomb group (PcG) factors maintain facultative heterochromatin and mediate many
important developmental and differentiation processes. EZH2, a PcG histone H3 lysine-27 …

Embryonic and postnatal life depend on the uninterrupted function of cardiac muscle cells.
These cells, termed cardiomyocytes, display many fascinating behaviors, including complex …

The polycomb repressor complex 2 molecule EZH2 is now known to play a role in essential
cellular processes, namely, cell fate decisions, cell cycle regulation, senescence, cell …

The ability to convert human somatic cells efficiently to neurons facilitates the utility of patient-
derived neurons for studying neurological disorders. As such, ectopic expression of …

Differentiation and activation of T cells require the activity of numerous histone lysine
methyltransferases (HMT) that control the transcriptional T cell output. One of the most potent …

Objective. To investigate the expression of HOX transcript antisense RNA (HOTAIR) in
cardiac tissues and plasma of patients with congenital heart diseases (CHDs). Methods …

The enzyme Poly (ADP-ribose) polymerase 1 (PARP1) plays a very important role in the
DNA damage response, but its role in numerous aspects is not fully understood. We recently …