The diversity, modularity, and efficacy of CRISPR-Cas systems are driving a
biotechnological revolution. RNA-guided Cas enzymes have been adopted as tools to …

Transposable elements (TEs) are major components of eukaryotic genomes. However, the
extent of their impact on genome evolution, function, and disease remain a matter of intense …

To date, almost 2600 gene therapy clinical trials have been completed, are ongoing or have
been approved worldwide. Our database brings together global information on gene therapy …

Although the clinical demand for bioengineered blood vessels continues to rise, current
options for vascular conduits remain limited. The synergistic combination of emerging …

The pancreas is made from two distinct components: the exocrine pancreas, a reservoir of
digestive enzymes, and the endocrine islets, the source of the vital metabolic hormone …

The human population is growing, and as a result we need to produce more food whilst
reducing the impact of farming on the environment. Selective breeding and genomic …

Artificial nuclease-dependent DNA cleavage systems (zinc-finger nuclease, ZFN;
transcription activator like effectors, TALENs) and exogenous nucleic acid defense systems …

Hurdles exist to clinical xenotransplantation including potential infectious transmission from
nonhuman species to xenograft recipients. In anticipation of clinical trials of …

Pigs serve as an important agricultural resource and animal model in biomedical studies.
Efficient and precise modification of pig genome by using recently developed gene editing …

Porcine endogenous retroviruses (PERVs) are present in the genome of all pigs, they infect
certain human cells and therefore pose a special risk for xenotransplantation using pig cells …