The prevalence of obesity in combination with sarcopenia (the age-related loss of muscle
mass and strength or physical function) is increasing in adults aged 65 years and older. A …

Background Endogenous sex hormones are important for metabolic health in men and
women. Before menopause, women are protected from atherosclerotic cardiovascular …

Abstract Objective To update the “Testosterone Therapy in Men With Androgen Deficiency
Syndromes” guideline published in 2010. Participants The participants include an Endocrine …

Purpose: There has been a marked increase in testosterone prescriptions in the past
decade resulting in a growing need to give practicing clinicians proper guidance on the …

Abstract The Testosterone Trials (TTrials) were a coordinated set of seven placebo-
controlled, double-blind trials in 788 men with a mean age of 72 years to determine the …

Frailty is a condition characterised by loss of biological reserves, failure of homoeostatic
mechanisms, and vulnerability to adverse outcomes. The endocrine system is considered …

Frailty, the state of increased vulnerability to physical stressors as a result of progressive and
sustained degeneration in multiple physiological systems, is common in those with chronic …

Introduction A rapid increase in awareness of androgen deficiency has led to substantial
increases in prescribing of testosterone therapy (TTh), with benefits of improvements in …

Background The relationship between testosterone (T) and cardiovascular (CV) risk in men
is conflicting. Aim To verify whether T therapy (TTh) represents a possible risk factor for CV …

This review examines the relationship between exogenous sex steroids and cardiovascular
events and surrogate markers in trans (transgender) people. Data from trans populations is …