Early detection of and intervention in childhood adversity has powerful potential to improve
the health and well-being of children. A systematic review was conducted to better …

Research on mechanisms underlying fetal programming of health and disease risk has
focused primarily on processes that are specific to cell types, organs or phenotypes of …

The geroscience hypothesis posits that therapies to slow biological processes of aging can
prevent disease and extend healthy years of life. To test such “geroprotective” therapies in …

Early adversity, in the form of abuse, neglect, socioeconomic status and other adverse
experiences, is associated with poor physical and mental health outcomes. To understand …

This manuscript reviews recent evidence supporting the utility of telomeres and
mitochondrial DNA copy number (mtDNAcn) in detecting the biological impacts of adverse …

Childhood adversity negatively impacts the biological development of children and has
been linked to poor health outcomes across the life course. The purpose of this literature …

Violence within families and child neglect are strikingly common: 700,000 children are found
to be victims of abuse or neglect in the United States each year; over the course of …

Telomeres play an important part in aging and show relationships to lifetime adversity,
particularly childhood adversity. Meta-analyses demonstrate reliable associations between …

Adverse childhood experiences (ACEs) have been identified as a key risk factor associated
with a wide range of negative life outcomes, including juvenile delinquency. Much less work …

Telomeres are specialised structures at the end of linear chromosomes. They consist of
tandem repeats of the hexanucleotide sequence TTAGGG, as well as a protein complex …