Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …

Most neurodegenerative diseases are proteinopathies, which are characterized by the
aggregation of misfolded proteins. Although many proteins have an intrinsic propensity to …

Abstract Alzheimer's Disease (AD), the most prevalent neurodegenerative disease of aging,
affects one in eight older Americans. Nearly all drug treatments tested for AD today have …

Alzheimer's disease (AD) is characterized by progressive memory loss and cognitive
function deficits. There are two major pathological hallmarks that contribute to the …

The mechanisms underpinning concussion, traumatic brain injury, and chronic traumatic
encephalopathy, and the relationships between these disorders, are poorly understood. We …

Tau, a microtubule-associated protein, is the main component of the intracellular filamentous
inclusions that are involved in neurodegenerative diseases known as tauopathies, including …

Classical microtubule‐associated proteins (MAPs) were originally identified based on their
co‐purification with microtubules assembled from mammalian brain lysate. They have since …

Arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) combination safely cures fatal acute
promyelocytic leukemia, but their mechanisms of action and efficacy are not fully …

Traumatic brain injury is a risk factor for subsequent neurodegenerative disease, including
chronic traumatic encephalopathy, a tauopathy mostly associated with repetitive concussion …

The post-injury inflammatory response is a key mediator in long-term recovery from
traumatic brain injury (TBI). Moreover, the immune response to TBI, mediated by microglia …