Monoclonal antibody (mAb)-based therapeutics are playing an increasingly important role in
the treatment or prevention of many important diseases such as cancers, autoimmune …

Over the last decade, the term process intensification (PI) has been applied almost
exclusively to large scale chemical processes, but hardly to aspects of biopharmaceutical …

In therapeutic monoclonal antibody (mAb) development, charge heterogeneity of a mAb
molecule is often associated with critical quality attributes and is therefore monitored …

Antibody-drug conjugates (ADC) represent an emerging, novel class of biopharmaceuticals.
The heterogeneity originating from the sophisticated structure requires orthogonal analytical …

Reversed phase liquid chromatography (RPLC) of therapeutic monoclonal antibodies
(mAbs) is often performed at elevated temperatures (80–90° C) and in the presence of …

Recently, antibody fragments have been studied as therapeutic agents because they lack Fc
effector function while having affinity similar to their original monoclonal antibody and can be …

Compounding of monoclonal antibody (mAbs) constantly increases in hospital. Quality
control (QC) of the compounded mAbs based on quantification and identification is required …

Ion exchange chromatography is widely used for charge variant analysis of proteins,
including monoclonal antibodies. In this study, a simple and robust salt gradient cation …

Abstract The monoclonal antibody Denosumab (DmAb) is clinically used to treat
osteoporosis and bone loss. We developed a bioassay based on the ability of DmAb to …

The effects of different ultrasonic powers, times and temperatures on the physicochemical
properties of bovine serum albumin (BSA)–galactose conjugates were investigated. SDS …