Primary microcephaly (MCPH, for “microcephaly primary hereditary”) is a disorder of brain
development that results in a head circumference more than 3 standard deviations below …

Cerebral cortical development involves a complex series of highly regulated steps to
generate the laminated structure of the adult neocortex. Neuronal migration is a key part of …

Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology.
Understanding the genetic factors contributing to the shared and disorder-specific symptoms …

Greenfield's Neuropathology, the world's leading neuropathology reference, provides a
comprehensive account of the pathological findings in neurological disease, their biological …

The cerebral cortex is composed of billions of morphologically and functionally distinct
neurons. These neurons are produced and organized in a regimental fashion during …

Periventricular nodular heterotopia (PVNH) is a malformation of cortical development
commonly associated with epilepsy. We exome sequenced 202 individuals with sporadic …

During development of the peripheral nervous system in mammals, Schwann cells wrap
their plasma membranes around neuronal axons, forming multiple myelin sheaths. A mature …

Disorders of neuronal mispositioning during brain development are phenotypically
heterogeneous and their genetic causes remain largely unknown. Here, we report biallelic …

PURPOSE OF REVIEW This article provides an overview of genetic metabolic disorders that
can be identified by metabolic tests readily available to neurologists, such as tests for …

Intracellular organelles, including secretory vesicles, emerged when eukaryotic cells
evolved some 3 billion years ago. The primordial organelles that evolved in Archaea were …