Human carbonic anhydrase (CA) IX is a tumor‐associated protein, since it is scarcely
present in normal tissues, but highly overexpressed in a large number of solid tumors, where …

Introduction: Human carbonic anhydrases (CA, EC 4.2. 1.1) IX and XII are tumor-associated
proteins, being part of the molecular machinery that tumor cells build as adaptive responses …

Hybridization is emerged as a promising strategy in the discovery of new drugs, especially
these with complimentary activities and multiple pharmacological targets that are the …

Sulfonamide carbonic anhydrase (CA, EC 4.2. 1.1) inhibitors targeting the α-class enzyme
from the protozoan pathogen Trypanosoma cruzi, responsible of Chagas disease, were …

The design, synthesis and biological evaluation of a library of 1, 2, 3-triazole carboxylates
incorporating carboxylic acid, hydroxymethyl, carboxylic acid hydrazide, carboxamide and …

The β-carbonic anhydrase (CA, EC 4.2. 1.1) from Leishmania spp.(LdcCA) is effectively
inhibited by aromatic/heterocyclic sulphonamides, in the low nanomolar range, but no in …

A small library of psoralen carboxylic acids and their corresponding benzenesulfonamide
derivatives were designed and synthesized to evaluate their activity and selectivity toward …

In the present study, a planning strategy for N‐substituted‐5‐arylidenerhodanines was
developed by the condensation between 3‐morpholinopropan‐1‐amine, aldehyde, ethyl …

In this work we describe the synthesis and characterization of two supramolecular
coordination complexes, namely [Zn (Cuma) 2 (MeOH) 2] 2 and [Mn (Cuma) 2 (MeOH) 2] 3 …

Carbonic anhydrases (CAs) are essential enzymes in biological processes. Prediction of the
activity of compounds towards CA isoforms could be evaluated by computational techniques …