Gene-based tests to study the combined effect of rare variants on a particular phenotype
have been widely developed for case-control studies, but their evolution and adaptation for …

This study describes the role of two STAT 6 gene variants in food allergy using data of
patients and their parents who underwent double‐blind placebo‐controlled food challenges …

Paracoccidioides is a thermodimorphic fungus that causes Paracoccidioidomycosis (PCM)–
an endemic systemic mycosis in Latin America. The genus comprises several phylogenetic …

Genome-wide association and fine-mapping studies have identified over 40 susceptibility
regions for type 1 diabetes (T1D), a common autoimmune disease; however, most of the …

Orofacial development is a multifaceted process involving tightly regulated genetic signaling
networks, that when perturbed, lead to orofacial abnormalities including cleft lip and/or cleft …

Paracoccidioidomycosis (PCM) is a neglected human systemic disease caused by species
of the genus Paracoccidioides. The disease attacks the host's lungs and may disseminate to …

Intracranial Aneurysm (IA) is a common disease with a worldwide prevalence of 1–3%. In
the French-Canadian (FC) population, where there is an important founder effect, the …

Background A Mendelian transmission produces phenotypic and genetic relatedness
between family members, giving family-based analytical methods an important role in …

Abstract Human Adenoviruses (HAdVs) are etiological agents of different syndromes such
as gastroenteritis, cystitis, ocular, and respiratory diseases, and infection by these viruses …

Several epidemiological and genetic studies have provided evidence of an overlap between
neurodevelopmental disorders. However, the details of the etiological pathways remain to …