Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

The improvement in survival of childhood cancer observed across the past 50 years has
resulted in a growing acknowledgment that simply extending the lifespan of survivors is not …

Background Among community-dwelling older adults, frailty is associated with heightened
markers of inflammation and subsequent mortality. Although frailty is common among end …

A serum biomarker of biological versus chronological age would have significant impact on
clinical care. It could be used to identify individuals at risk of early‐onset frailty or the …

Frailty denotes a multidimensional syndrome that gives rise to vulnerability to stressors and
leads to an increase of the age-related decline of different physiological systems and …

Neutrophil extracellular traps or NETs are released by highly activated neutrophils in
response to infectious agents, sterile inflammation, autoimmune stimuli and cancer. In the …

The definition of cognitive frailty and its prediction for adverse outcome of community-living
older adults remains controversial. This study aims to evaluate the association between …

Background Whether physical activity can reduce cognitive frailty—a relatively new
“compound” phenotype proposed in 2013—and whether the effect of physical activity differs …

Frailty is a progressive physiologic decline in multiple body systems, characterized by loss of
function, loss of physiologic reserve, and increased vulnerability to disease and death. This …

Sarcopenia and frailty are associated with several important health-related adverse events,
including disability, loss of independence, institutionalization and mortality. Sarcopenia can …