Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

Lysine-specific demethylase 1A (LSD1, also named KDM1A) is a demethylase that can
remove methyl groups from histones H3K4me1/2 and H3K9me1/2. It is aberrantly expressed …

Medical castration that interferes with androgen receptor (AR) function is the principal
treatment for advanced prostate cancer. However, clinical progression is universal, and …

Oncogene-induced senescence, eg, in melanocytic nevi, terminates the expansion of pre-
malignant cells via transcriptional silencing of proliferation-related genes due to decoration …

Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers.
Both late tumor diagnosis and tolerance to available chemical therapy increase patient …

Glioblastoma is one of the first tumors where the biological changes accompanying a single
epigenetic modification, the methylation of the MGMT gene, were found to be of clinical …

Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy characterized
by the accumulation of incompletely differentiated progenitor cells (blasts) in the bone …

Despite recent advances, the myeloproliferative neoplasms (MPNs) are attended by
considerable morbidity and mortality. Janus kinase (Jak) inhibitors such as ruxolitinib …

Abstract Lysine-specific demethylase 1 (LSD1) was the first histone demethylase identified
as catalysing the removal of mono-and di-methylation marks on histone H3-K4. Despite the …

The lysine-specific histone demethylase 1A (KDM1A) was the first demethylase to challenge
the concept of the irreversible nature of methylation marks. KDM1A, containing a flavin …