Gout–An update of aetiology, genetics, co-morbidities and management
PC Robinson - Maturitas, 2018 - Elsevier
Gout is an increasingly common chronic disorder of urate crystal deposition that manifests
as flares of acute inflammatory arthritis. Hyperuricaemia is a prerequisite and a fifth of both …
as flares of acute inflammatory arthritis. Hyperuricaemia is a prerequisite and a fifth of both …
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
Electronic health records: the next wave of complex disease genetics
BN Wolford, CJ Willer, I Surakka - Human molecular genetics, 2018 - academic.oup.com
The combination of electronic health records (EHRs) with genetic data has ushered in the
next wave of complex disease genetics. Population-based biobanks and other large cohorts …
next wave of complex disease genetics. Population-based biobanks and other large cohorts …
[PDF][PDF] Estimating SNP-based heritability and genetic correlation in case-control studies directly and with summary statistics
Methods that estimate SNP-based heritability and genetic correlations from genome-wide
association studies have proven to be powerful tools for investigating the genetic …
association studies have proven to be powerful tools for investigating the genetic …
[HTML][HTML] Interethnic analyses of blood pressure loci in populations of East Asian and European descent
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200
genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide …
genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide …
Molecular mechanisms for species differences in organic anion transporter 1, OAT1: implications for renal drug toxicity
Species differences in renal drug transporters continue to plague drug development with
animal models failing to adequately predict renal drug toxicity. For example, adefovir, a …
animal models failing to adequately predict renal drug toxicity. For example, adefovir, a …
[HTML][HTML] Glucose and insulin-related traits, type 2 diabetes and risk of schizophrenia: a Mendelian randomization study
Background The link between schizophrenia and diabetes mellitus is well established by
observational studies; however, the cause-effect relationship remains unclear. Methods …
observational studies; however, the cause-effect relationship remains unclear. Methods …
Revisiting the evolutionary origins of obesity: lazy versus peppy‐thrifty genotype hypothesis
The recent global obesity epidemic is attributed to major societal and environmental
changes, such as excessive energy intake and sedentary lifestyle. However, exposure to …
changes, such as excessive energy intake and sedentary lifestyle. However, exposure to …
Hidden 'risk'in polygenic scores: clinical use today could exacerbate health disparities
Polygenic risk scores have the potential to improve health outcomes for a variety of complex
diseases and are poised for clinical translation, driven by the low cost of genotyping (< $50 …
diseases and are poised for clinical translation, driven by the low cost of genotyping (< $50 …
[HTML][HTML] Exploring the genetic correlation between growth and immunity based on summary statistics of genome-wide association studies
Z Zhang, P Ma, Q Li, Q Xiao, H Sun, BS Olasege… - Frontiers in …, 2018 - frontiersin.org
The relationship between growth and immune phenotypes has been presented in the
context of physiology and energy allocation theory, but has rarely been explained …
context of physiology and energy allocation theory, but has rarely been explained …