[HTML][HTML] Curcumin and its derivatives as potential therapeutic agents in prostate, colon and breast cancers

Z Mbese, V Khwaza, BA Aderibigbe - Molecules, 2019 - mdpi.com
Cancer is a life-threatening disease and is the second leading cause of death around the
world. The increasing threats of drug-resistant cancers indicate that there is an urgent need …

[HTML][HTML] Curcumin as tyrosine kinase inhibitor in cancer treatment

A Golonko, H Lewandowska, R Świsłocka… - European Journal of …, 2019 - Elsevier
Curcumin is a natural substance known for ages, exhibiting a multidirectional effect in
cancer prevention and adjuvant cancer therapies. The great advantage of using …

Direct Amination and Synthesis of Fused N‐Substituted Isothiochromene Derivatives

AA Abu‐Hashem, MEA Zaki - Journal of Heterocyclic Chemistry, 2019 - Wiley Online Library
Isothiochromene [3, 4‐d] pyrimidine derivatives 2, 3, and 4a, b were synthesized from the
reaction of 3‐amino‐1‐(pyridin‐4‐yl)‐5‐(pyridin‐4‐ylmethylene)‐5, 6, 7, 8‐tetrahydro‐1H …

Cytotoxicity of curcumin derivatives in ALK positive non-small cell lung cancer

AR Bland, RL Bower, M Nimick, BC Hawkins… - European journal of …, 2019 - Elsevier
Non-small cell lung cancer with ALK rearrangements can be targeted effectively with ALK
inhibitors such as crizotinib. However, cancer progression typically occurs within a year as …

Raloxifene nano-micelles effect on triple-negative breast cancer is mediated through estrogen receptor-β and epidermal growth factor receptor

K Greish, H Nehoff, F Bahman, T Pritchard… - Journal of Drug …, 2019 - Taylor & Francis
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that differs
in progression, recurrence, and prognosis from other forms of breast cancer. The …

[HTML][HTML] A multivariate statistical analysis of the effects of styrene maleic acid encapsulated RL71 in a xenograft model of triple negative breast cancer

ONK Martey, K Greish, PF Smith… - Journal of Biological …, 2019 - ncbi.nlm.nih.gov
We have previously shown that the curcumin derivative 3, 5-bis (3, 4, 5-
trimethoxybenzylidene)-1-methylpiperidine-4-one (RL71), when encapsulated in styrene …

Preclinical Evaluation Of Curcumin And Its Meriva Formulation For Non-Small Cell Lung Cancer Chemoprevention

G Smagurauskaite - 2019 - figshare.le.ac.uk
The naturally derived polyphenol curcumin has been investigated for prevention and
treatment of many cancers over the past few decades. Accumulating evidence demonstrates …