Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming

S Sureshchandra, NE Marshall… - Journal of leukocyte …, 2019 - academic.oup.com
Maternal pregravid obesity results in several adverse health outcomes during pregnancy,
including increased risk of gestational diabetes, preeclampsia, placental abruption, and …

Obesity during pregnancy results in maternal intestinal inflammation, placental hypoxia, and alters fetal glucose metabolism at mid-gestation

JG Wallace, CJ Bellissimo, E Yeo, Y Fei Xia, JJ Petrik… - Scientific reports, 2019 - nature.com
We investigated whether diet-induced changes in the maternal intestinal microbiota were
associated with changes in bacterial metabolites and their receptors, intestinal inflammation …

Exercise prevents the adverse effects of maternal obesity on placental vascularization and fetal growth

JS Son, X Liu, Q Tian, L Zhao, Y Chen… - The Journal of …, 2019 - Wiley Online Library
Key points Maternal exercise improves the metabolic health of maternal mice challenged
with a high‐fat diet. Exercise intervention of obese mothers prevents fetal overgrowth …

Maternal diet‐induced obesity compromises oxidative stress status and angiogenesis in the porcine placenta by upregulating Nox2 expression

C Hu, Y Yang, J Li, H Wang, C Cheng… - Oxidative Medicine …, 2019 - Wiley Online Library
Maternal obesity is associated with placental oxidative stress. However, the mechanism
underlying this association remains poorly understood. In the present study, a gilt obesity …

The epigenetic machinery in the life cycle and pharmacoepigenetics

R Cacabelos, I Tellado, P Cacabelos - Pharmacoepigenetics, 2019 - Elsevier
Epigenetics is a discipline that studies potentially reversible heritable changes in gene
expression with no structural modifications in the DNA sequence. The epigenetic machinery …

Diabetic endothelial colony forming cells have the potential for restoration with glycomimetics

AWW Langford-Smith, A Hasan, R Weston… - Scientific Reports, 2019 - nature.com
Endothelial colony forming progenitor cell (ECFC) function is compromised in diabetes,
leading to poor vascular endothelial repair, which contributes to impaired diabetic foot ulcer …

Early life nutritional programming of adult health status

SC Langley-Evans, B Muhlhausler - Early life origins of ageing and …, 2019 - Springer
There is increasing recognition that the risk of a broad range of non-communicable
diseases, including obesity, cardiovascular disease and type 2 diabetes, are related not only …

[PDF][PDF] Diabetic endothelial colony forming cells have the potential for restoration with glycomimetics

FL Wilkinson, MY Alexander - e-space.mmu.ac.uk
Results Demographics. Patients with type 2 diabetes who were recruited into the study were
aged between 59.6 (SD±10.4) and 64.7 (SD±10.1) years in the NP and NI groups …