Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD), increasing risk and decreasing age of disease onset. Many studies have demonstrated the …
Abstract Neuregulin-1 (Nrg-1) is a member of the Neuregulin family of growth factors with essential roles in the developing and adult nervous system. Six different types of Nrg-1 (Nrg …
P Dong, H Wang, XF Shen, P Jiang, XT Zhu, Y Li… - Nature …, 2019 - nature.com
Flight, an active fear response to imminent threat, is dependent on the rapid risk assessment of sensory information processed by the cortex. The thalamic reticular nucleus (TRN) filters …
The cellular activity underlying human focal seizures, and its relationship to key signatures in the EEG recordings used for therapeutic purposes, has not been well characterized …
D Debanne, M Russier - Neurobiology of learning and memory, 2019 - Elsevier
Persistent changes that occur in brain circuits are classically thought to be mediated by long- term modifications in synaptic efficacy. Yet, many studies have shown that voltage-gated ion …
TMEM16B (ANO2) is the Ca2+-activated chloride channel expressed in multiple brain regions, including the amygdala. Here we report that Ano2 knockout mice exhibit impaired …
N Shigematsu, A Nishi, T Fukuda - Cerebral Cortex, 2019 - academic.oup.com
Parvalbumin (PV)-positive interneurons form dendritic gap junctions with one another, but the connectivity among gap junction-coupled dendrites remains uninvestigated in most …
JM Yang, CJ Shen, XJ Chen, Y Kong, YS Liu… - Cerebral …, 2019 - academic.oup.com
Abstract erbb4 is a known susceptibility gene for schizophrenia. Chandelier cells (ChCs, also known as axo-axonic cells) are a distinct GABAergic interneuron subtype that …
HY Kim, YR Yang, H Hwang, HE Lee, HJ Jang, J Kim… - Scientific reports, 2019 - nature.com
Synaptic inhibition plays a fundamental role in the information processing of neural circuits. It sculpts excitatory signals and prevents hyperexcitability of neurons. Owing to these …