Plasticity of intrinsic neuronal excitability

D Debanne, Y Inglebert, M Russier - Current opinion in neurobiology, 2019 - Elsevier
Highlights•Voltage-gated ion channels participate in memory formation.•Intrinsic plasticity is
not only global but it might be also local.•Intrinsic plasticity shares common learning rules …

[HTML][HTML] Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease

R Najm, EA Jones, Y Huang - Molecular neurodegeneration, 2019 - Springer
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD),
increasing risk and decreasing age of disease onset. Many studies have demonstrated the …

Neuregulin-1/ErbB network: An emerging modulator of nervous system injury and repair

H Kataria, A Alizadeh, S Karimi-Abdolrezaee - Progress in neurobiology, 2019 - Elsevier
Abstract Neuregulin-1 (Nrg-1) is a member of the Neuregulin family of growth factors with
essential roles in the developing and adult nervous system. Six different types of Nrg-1 (Nrg …

A novel cortico-intrathalamic circuit for flight behavior

P Dong, H Wang, XF Shen, P Jiang, XT Zhu, Y Li… - Nature …, 2019 - nature.com
Flight, an active fear response to imminent threat, is dependent on the rapid risk assessment
of sensory information processed by the cortex. The thalamic reticular nucleus (TRN) filters …

Multiscale recordings reveal the dynamic spatial structure of human seizures

CA Schevon, S Tobochnik, T Eissa, E Merricks… - Neurobiology of …, 2019 - Elsevier
The cellular activity underlying human focal seizures, and its relationship to key signatures
in the EEG recordings used for therapeutic purposes, has not been well characterized …

The contribution of ion channels in input-output plasticity

D Debanne, M Russier - Neurobiology of learning and memory, 2019 - Elsevier
Persistent changes that occur in brain circuits are classically thought to be mediated by long-
term modifications in synaptic efficacy. Yet, many studies have shown that voltage-gated ion …

TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala

KX Li, M He, W Ye, J Simms, M Gill, X Xiang, YN Jan… - Elife, 2019 - elifesciences.org
TMEM16B (ANO2) is the Ca2+-activated chloride channel expressed in multiple brain
regions, including the amygdala. Here we report that Ano2 knockout mice exhibit impaired …

Gap junctions interconnect different subtypes of parvalbumin-positive interneurons in barrels and septa with connectivity unique to each subtype

N Shigematsu, A Nishi, T Fukuda - Cerebral Cortex, 2019 - academic.oup.com
Parvalbumin (PV)-positive interneurons form dendritic gap junctions with one another, but
the connectivity among gap junction-coupled dendrites remains uninvestigated in most …

erbb4 Deficits in Chandelier Cells of the Medial Prefrontal Cortex Confer Cognitive Dysfunctions: Implications for Schizophrenia

JM Yang, CJ Shen, XJ Chen, Y Kong, YS Liu… - Cerebral …, 2019 - academic.oup.com
Abstract erbb4 is a known susceptibility gene for schizophrenia. Chandelier cells (ChCs,
also known as axo-axonic cells) are a distinct GABAergic interneuron subtype that …

[HTML][HTML] Deletion of PLCγ1 in GABAergic neurons increases seizure susceptibility in aged mice

HY Kim, YR Yang, H Hwang, HE Lee, HJ Jang, J Kim… - Scientific reports, 2019 - nature.com
Synaptic inhibition plays a fundamental role in the information processing of neural circuits.
It sculpts excitatory signals and prevents hyperexcitability of neurons. Owing to these …