The role of FOXP3+ regulatory T cells in human autoimmune and inflammatory diseases

A Mohr, M Atif, R Balderas, G Gorochov… - Clinical & …, 2019 - academic.oup.com
CD4+ regulatory T cells (Treg) expressing the forkhead box protein 3 (FOXP3) transcription
factor (Tregs) are instrumental for the prevention of autoimmune diseases. There is …

[HTML][HTML] Lamiaceae: an insight on their anti-allergic potential and its mechanisms of action

LY Sim, NZ Abd Rani, K Husain - Frontiers in pharmacology, 2019 - frontiersin.org
The prevalence of allergic diseases such as asthma, allergic rhinitis, food allergy and atopic
dermatitis has increased dramatically in recent decades. Conventional therapies for allergy …

[HTML][HTML] Oral administration of β-glucan and lactobacillus plantarum alleviates atopic dermatitis-like symptoms

IS Kim, SH Lee, YM Kwon, B Adhikari, JA Kim, GI Kim… - 2019 - jmb.or.kr
Atopic dermatitis (AD) is a chronic inflammatory skin disease of mainly infants and children.
Currently, the development of safe and effective treatments for AD is urgently required. The …

[HTML][HTML] Inflammatory patterns of antrochoanal polyps in the pediatric age group

H Zheng, L Tang, B Song, X Yang, P Chu… - Allergy, Asthma & …, 2019 - Springer
Background The pathogenesis and etiology of antrochoanal polyps (ACPs) remains
obscure. This study aimed to characterize the inflammatory profiles and investigate the effect …

[HTML][HTML] A significant decrease in the gene expression of interleukin-17 following the administration of synbiotic in patients with allergic rhinitis who underwent …

S Dehnavi, FJ Azad, RF Hoseini… - Journal of Research …, 2019 - journals.lww.com
Background: Allergic Rhinitis (AR) is the most common allergic disease worldwide. The
present study, evaluated effects of synbiotic on gene expression of interferon-gamma (IFN …

Engineered ovalbumin-expressing regulatory T cells protect against anaphylaxis in ovalbumin-sensitized mice

M Abdeladhim, AH Zhang, LE Kropp, AR Lindrose… - Clinical …, 2019 - Elsevier
Allergy is a major public health concern, the main treatment for which is symptomatic relief
with anti-inflammatory drugs. A key clinical challenge is to induce specific tolerance in order …

Complexation of whey protein with caffeic acid or (−)-epigallocatechin-3-gallate as a strategy to induce oral tolerance to whey allergenic proteins

TB Pessato, NC de Carvalho, D de Figueiredo… - International …, 2019 - Elsevier
Proteins and phenolic compounds can interact and form soluble and insoluble complexes.
In this study, the complexation of whey protein isolate (WPI) with caffeic acid (CA) or (−) …

Co-delivery of allergen epitope fragments and R848 inhibits food allergy by inducing tolerogenic dendritic cells and regulatory T cells

J Hong, X Xiao, Q Gao, S Li, B Jiang… - International Journal …, 2019 - Taylor & Francis
Background Food allergy (FA) is a significant public health problem. The therapeutic efficacy
for FA is unsatisfactory currently. The breakdown of intestinal immune tolerance is …

[HTML][HTML] Staphylococcus succinus 14BME20 Prevents Allergic Airway Inflammation by Induction of Regulatory T Cells via Interleukin-10

J Song, HX Lim, A Lee, S Kim, JH Lee… - Frontiers in …, 2019 - frontiersin.org
Asthma is a common chronic inflammatory disease, which is characterized by airway
hyperresponsiveness (AHR), high serum levels of immunoglobulin (Ig) E, and recruitment of …

Regulatory T cells for more targeted immunosuppressive therapies

H Allos, BS Al Dulaijan, J Choi… - Clinics in laboratory …, 2019 - labmed.theclinics.com
The adaptive immune system thrives on its foundational ability to create an almost
innumerable repertoire of randomly assorted T-cell receptors (TCRs), including those toward …