[HTML][HTML] Human cytomegalovirus genomics and transcriptomics through the lens of next-generation sequencing: revision and future challenges

J Martí-Carreras, P Maes - Virus Genes, 2019 - Springer
The human cytomegalovirus (HCMV) genome was sequenced by hierarchical shotgun
almost 30 years ago. Over these years, low and high passaged strains have been …

Congenital and perinatal infections

B Ostrander, JF Bale - Handbook of clinical neurology, 2019 - Elsevier
Congenital and perinatal infections represent major causes of permanent disability among
children worldwide. Linked together by the acronym TORCH, denoting Toxoplasma gondii …

Human cytomegalovirus haplotype reconstruction reveals high diversity due to superinfection and evidence of within-host recombination

J Cudini, S Roy, CJ Houldcroft… - Proceedings of the …, 2019 - National Acad Sciences
Recent sequencing efforts have led to estimates of human cytomegalovirus (HCMV)
genome-wide intrahost diversity that rival those of persistent RNA viruses [Renzette N …

Human cytomegalovirus genomes sequenced directly from clinical material: variation, multiple-strain infection, recombination, and gene loss

NM Suárez, GS Wilkie, E Hage… - The Journal of …, 2019 - academic.oup.com
The genomic characteristics of human cytomegalovirus (HCMV) strains sequenced directly
from clinical pathology samples were investigated, focusing on variation, multiple-strain …

Congenital cytomegalovirus infection

ML Dietrich, JS Schieffelin - Ochsner Journal, 2019 - ochsnerjournal.org
Background: Congenital cytomegalovirus (cCMV) is the leading cause of nongenetic
congenital hearing loss in much of the world and a leading cause of neurodevelopmental …

[HTML][HTML] Cytokine-mediated induction and regulation of tissue damage during cytomegalovirus infection

M Clement, IR Humphreys - Frontiers in immunology, 2019 - frontiersin.org
Human cytomegalovirus (HCMV) is a β-herpesvirus with high sero-prevalence within the
human population. Primary HCMV infection and life-long carriage are typically …

[HTML][HTML] Persistent infection with herpes simplex virus 1 and Alzheimer's disease—a call to study how variability in both virus and host may impact disease

CA Mangold, ML Szpara - Viruses, 2019 - mdpi.com
Increasing attention has focused on the contributions of persistent microbial infections with
the manifestation of disease later in life, including neurodegenerative conditions such as …

Multiple-strain infections of human cytomegalovirus with high genomic diversity are common in breast milk from human immunodeficiency virus–infected women in …

NM Suárez, KG Musonda, E Escriva… - The Journal of …, 2019 - academic.oup.com
Background In developed countries, human cytomegalovirus (HCMV) is a major pathogen in
congenitally infected and immunocompromised individuals, where multiple-strain infection …

[HTML][HTML] Distribution of the CMV glycoprotein gH/gL/gO and gH/gL/pUL128/pUL130/pUL131A complex variants and associated clinical manifestations in infants …

E Paradowska, A Jabłońska, M Studzińska… - Scientific reports, 2019 - nature.com
Human cytomegalovirus (CMV) is a major cause of morbidity in fetuses following intrauterine
infection. The glycoprotein (g) envelope trimeric gH/gL/gO and pentameric gH/gL/pUL128 …

Genotypic and phenotypic diversity of herpes simplex virus 2 within the infected neonatal population

LN Akhtar, CD Bowen, DW Renner, U Pandey… - MSphere, 2019 - Am Soc Microbiol
More than 14,000 neonates are infected with herpes simplex virus (HSV) annually.
Approximately half display manifestations limited to the skin, eyes, or mouth (SEM disease) …