S Akocak, CT Supuran - Journal of enzyme inhibition and …, 2019 - Taylor & Francis
Eight genetically distinct carbonic anhydrase (EC 4.2. 1.1) enzyme families (α-, β-, γ-δ-, ζ-, η- , θ-and ι-CAs) were described to date. On the other hand, 16 mammalian α-CA isoforms are …
Herein we describe the design and synthesis of two series of sulfonamides featuring N- unsubstituted (4a-c) or N-substituted (7a-o) isatin moieties (as tails) connected to …
S Bua, L Lucarini, L Micheli, M Menicatti… - Journal of Medicinal …, 2019 - ACS Publications
Multitarget nonsteroidal anti-inflammatory drug (NSAID)–carbonic anhydrase inhibitor (CAI) agents for the management of rheumatoid arthritis are reported. The evidence of the plasma …
Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) catalyze the interconversion between CO 2 and bicarbonate as well as other hydrolytic reactions. Seven genetic families of CAs have …
In the presented work, we report the synthesis of a series of 4-benzylidene-2-phenyl-5 (4H)- imidazolone-based benzenesulfonamides 7a-f via the Erlenmeyer–Plöchl reaction. All the …
Herein, we report the synthesis, characterization, and carbonic anhydrase (CA) inhibition of the newly synthesized Schiff's bases 4–18 with benzenesulfonamide, methanesulfonamide …
In this work, we present the synthesis and biological evaluation of novel series of diamide- based benzenesulfonamides 5a–h as inhibitors of the metalloenzyme carbonic anhydrase …
Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) are crucial metalloenzymes that are involved in diverse bioprocesses. We report the synthesis and biological evaluation of novel …