Precise genetic and epigenetic spatiotemporal regulation of gene expression is critical for
proper brain development, function and circuitry formation in the mammalian central nervous …

Cardiometabolic and vascular disease, with their associated secondary complications, are
the leading cause of morbidity and mortality in Western society. Chronic inflammation is a …

The present invention relates to a pharmaceutical composi tion comprising a modified
mRNA that is stabilized by sequence modifications and optimized for translation. The …

Acetylation is a posttranslational modification conserved in all domains of life that is carried
out by N-acetyltransferases. While acetylation can occur on N α-amino groups, this review …

2013-03-19 Assigned to modeRNA Therapeutics reassignment modeRNA Therapeutics
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …

Epigenetic and metabolic alterations incancer cells are highly associated. Glioblastoma
multiforme (GBM) is a complicated pathological process with dysregulated methylation and …

The reversible acetylation of lysine side chains on the surfaces of enzymes and other
proteins comprises a vital regulatory strategy in myriad cellular processes such as …

Posttranslational modification of a protein, either alone or in combination with other
modifications, can control properties of that protein, such as enzymatic activity, localization …

Photomorphogenesis is a critical plant developmental process that involves light-mediated
transcriptome and histone modification changes. The transcription factor ELONGATED …

Histone deacetylase inhibitors (HDACi) are a relatively new class of drug that plays an
important role in the epigenetic and non-epigenetic regulation in cancer, inducing death …