New therapies that promote antitumour immunity have been recently developed. Most of
these immunomodulatory approaches have focused on enhancing T-cell responses, either …

Cellular senescence is a permanent state of cell cycle arrest that occurs in proliferating cells
subjected to different stresses. Senescence is, therefore, a cellular defense mechanism that …

Retrotransposable elements are deleterious at many levels, and the failure of host
surveillance systems for these elements can thus have negative consequences. However …

Cellular senescence plays a critical role in tumorigenesis. Once thought of as a tissue
culture artefact by some researchers, senescence is now a major field of study. Although …

BACKGROUND The life of any organism depends on the ability of cells to accurately
recognize and eliminate harmful microbes. To detect the immense repertoire of pathogenic …

Cellular senescence is implicated in physiological and pathological processes spanning
development, wound healing, age-related decline in organ functions and cancer. Here, we …

The senescence-associated secretory phenotype (SASP) defines the ability of senescent
cells to express and secrete a variety of extracellular modulators that includes cytokines …

Radiotherapy is used in> 50% of patients with cancer, both for curative and palliative
purposes. Radiotherapy uses ionizing radiation to target and kill tumour tissue, but normal …

Cellular senescence entails a stable cell-cycle arrest and a pro-inflammatory secretory
phenotype, which contributes to aging and age-related diseases. Obesity is associated with …

Organismal ageing is a complex process driving progressive impairment of functionality and
regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest …