Current knowledge of germline genetic risk factors for the development of non-medullary thyroid cancer

K Hińcza, A Kowalik, A Kowalska - Genes, 2019 - mdpi.com
The thyroid is the most common site of endocrine cancer. One type of thyroid cancer, non-
medullary thyroid cancer (NMTC), develops from follicular cells and represents …

Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells through suppression of EGFR/RAS/RAF/MEK/ERK …

D Wu, Z Liu, J Li, Q Zhang, P Zhong, T Teng… - Cancer cell …, 2019 - Springer
Background Thyroid cancer is the most common type of endocrine malignancy and the
incidence rate is rapidly increasing worldwide. Epigallocatechin-3-gallate (EGCG) could …

Whole exome and target sequencing identifies MAP2K5 as novel susceptibility gene for familial non‐medullary thyroid carcinoma

F Ye, H Gao, L Xiao, Z Zuo, Y Liu… - … journal of cancer, 2019 - Wiley Online Library
Although the genotype–phenotype for familial medullary thyroid carcinoma (FMTC) is well
studied, only few low susceptibility risk loci were identified for familial non‐medullary thyroid …

Whole genome sequencing of familial non-medullary thyroid cancer identifies germline alterations in MAPK/ERK and PI3K/AKT signaling pathways

A Srivastava, A Kumar, S Giangiobbe, E Bonora… - Biomolecules, 2019 - mdpi.com
Evidence of familial inheritance in non-medullary thyroid cancer (NMTC) has accumulated
over the last few decades. However, known variants account for a very small percentage of …

Genetic variants implicate dual oxidase-2 in familial and sporadic nonmedullary thyroid cancer

DV Bann, Q Jin, KE Sheldon, KR Houser, L Nguyen… - Cancer Research, 2019 - AACR
Highly penetrant hereditary thyroid cancer manifests as familial nonmedullary thyroid cancer
(FNMTC), whereas low-penetrance hereditary thyroid cancer manifests as sporadic disease …

NOP53 as A Candidate Modifier Locus for Familial Non-Medullary Thyroid Cancer

A Orois, SK Gara, M Mora, I Halperin, S Martínez… - Genes, 2019 - mdpi.com
Nonsyndromic familial non-medullary thyroid cancer (FNMTC) represents 3–9% of thyroid
cancers, but the susceptibility gene (s) remain unknown. We designed this multicenter study …

Gsslasso Cox: a Bayesian hierarchical model for predicting survival and detecting associated genes by incorporating pathway information

Z Tang, S Lei, X Zhang, Z Yi, B Guo, JY Chen… - BMC …, 2019 - Springer
Background Group structures among genes encoded in functional relationships or biological
pathways are valuable and unique features in large-scale molecular data for survival …

Characterization of the enzymatic activity of the serine protease domain of Factor VII activating protease (FSAP)

NV Nielsen, E Roedel, D Manna, M Etscheid… - Scientific Reports, 2019 - nature.com
Factor VII (FVII) activating protease (FSAP) is a circulating serine protease. Human genetic
studies, based on the Marburg I (MI)(Gly221Glu, chymotrypsin numbering system) …

Targeted next-generation sequencing in papillary thyroid carcinoma patients looking for germline variants predisposing to the disease

CT Shen, GQ Zhang, ZL Qiu, HJ Song, ZK Sun, QY Luo - Endocrine, 2019 - Springer
Purposess The purpose of this study was using next-generation sequencing technique to
explore the potential association between germline variants of 14 targeted genes and …

VEGF-A-cleavage by FSAP and inhibition of neo-vascularization

Ö Uslu, J Herold, S M. Kanse - Cells, 2019 - mdpi.com
Alternative splicing leads to the secretion of multiple forms of vascular endothelial growth
factor-A (VEGF-A) that differ in their activity profiles with respect to neovascularization. FSAP …