Psoriasis is chronic inflammatory skin disease affecting skin, joints, cardiovascular system,
brain, and metabolism. The pathogenesis of psoriasis is mediated by a complex interplay …

Psoriasis is multifactorial disease with complex genetic predisposition. Recent advances in
genetics and genomics analyses have provided many insights into the relationship between …

Psoriatic arthritis (PsA) is an inflammatory arthritis that manifests in 20–30% of patients
diagnosed with psoriasis. Epidemiologic studies suggest a substantial genetic contribution …

Psoriasis is an inflammatory skin disease with a background of polygenic inheritance. Both
environmental and genetic factors are involved in the etiology of the disease. In the last two …

Maintenance of high-turnover tissues such as the epidermis requires a balance between
stem cell proliferation and differentiation. The molecular mechanisms governing this process …

Recent evidences had shown activation of TLR (toll-like receptors) and NLR (nod-like
receptors) in response to imbalance in nutrients intake, such as lipid and glucose. The main …

Background Methotrexate (MTX) is an efficacious treatment for psoriasis; however, its
widespread application is limited by its unpredictable efficacy. Objectives To investigate the …

Objective A 2-stage genome-wide association was conducted to explore the genetic etiology
of amyotrophic lateral sclerosis (ALS) in the Chinese Han population. Methods Totally, 700 …

Psoriasis is a chronic inflammatory skin disease. Keratinocytes (KCs), as skin‑specific cells,
serve an important role in the immunopathogenesis of psoriasis. In the present study …

Inorganic arsenic (As) is a toxic xenobiotic and carcinogen associated with severe health
conditions. The urban population from the Atacama Desert in northern Chile was exposed to …