[HTML][HTML] Defining the genetic, genomic, cellular, and diagnostic architectures of psychiatric disorders
PF Sullivan, DH Geschwind - Cell, 2019 - cell.com
Studies of the genetics of psychiatric disorders have become one of the most exciting and
fast-moving areas in human genetics. A decade ago, there were few reproducible findings …
fast-moving areas in human genetics. A decade ago, there were few reproducible findings …
Microbiome–microglia connections via the gut–brain axis
R Abdel-Haq, JCM Schlachetzki, CK Glass… - Journal of Experimental …, 2019 - rupress.org
Microglia, the resident immune cells in the brain, are essential for modulating neurogenesis,
influencing synaptic remodeling, and regulating neuroinflammation by surveying the brain …
influencing synaptic remodeling, and regulating neuroinflammation by surveying the brain …
Human gut microbiota from autism spectrum disorder promote behavioral symptoms in mice
Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors
including social communication and stereotypies. In addition to genetic risks, the gut …
including social communication and stereotypies. In addition to genetic risks, the gut …
Single-cell genomics identifies cell type–specific molecular changes in autism
Despite the clinical and genetic heterogeneity of autism, bulk gene expression studies show
that changes in the neocortex of autism patients converge on common genes and pathways …
that changes in the neocortex of autism patients converge on common genes and pathways …
Inherited and de novo genetic risk for autism impacts shared networks
We performed a comprehensive assessment of rare inherited variation in autism spectrum
disorder (ASD) by analyzing whole-genome sequences of 2,308 individuals from families …
disorder (ASD) by analyzing whole-genome sequences of 2,308 individuals from families …
The fetal origins of mental illness
BJS Al-Haddad, E Oler, B Armistead… - American journal of …, 2019 - Elsevier
The impact of infections and inflammation during pregnancy on the developing fetal brain
remains incompletely defined, with important clinical and research gaps. Although the …
remains incompletely defined, with important clinical and research gaps. Although the …
Getting to the cores of autism
The genetic architecture of autism spectrum disorder (ASD) is itself a diverse allelic
spectrum that consists of rare de novo or inherited variants in hundreds of genes and …
spectrum that consists of rare de novo or inherited variants in hundreds of genes and …
Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons
Autism spectrum disorder (ASD) is thought to emerge during early cortical development.
However, the exact developmental stages and associated molecular networks that prime …
However, the exact developmental stages and associated molecular networks that prime …
Neuron-glia signaling in synapse elimination
DK Wilton, L Dissing-Olesen… - Annual review of …, 2019 - annualreviews.org
Maturation of neuronal circuits requires selective elimination of synaptic connections.
Although neuron-intrinsic mechanisms are important in this process, it is increasingly …
Although neuron-intrinsic mechanisms are important in this process, it is increasingly …
Genetics and epigenetics of autism spectrum disorder—current evidence in the field
B Wiśniowiecka-Kowalnik, BA Nowakowska - Journal of applied genetics, 2019 - Springer
Autism spectrum disorders (ASD) is a heterogenous group of neurodevelopmental disorders
characterized by problems in social interaction and communication as well as the presence …
characterized by problems in social interaction and communication as well as the presence …