Βeta-sitosterol enhances motor coordination, attenuates memory loss and demyelination in a vanadium-induced model of experimental neurotoxicity

OE Adebiyi, FO Olayemi, JO Olopade, NH Tan - Pathophysiology, 2019 - Elsevier
Environmental discharge of vanadium causes cognitive and behavioral impairments in
humans and animals via production of reactive oxygen species leading to lipid peroxidation …

[HTML][HTML] Stabilization of the cardiac sarcolemma by sarcospan rescues DMD-associated cardiomyopathy

MS Parvatiyar, AJ Brownstein… - JCI insight, 2019 - ncbi.nlm.nih.gov
In the current preclinical study, we demonstrate the therapeutic potential of sarcospan
(SSPN) overexpression to alleviate cardiomyopathy associated with Duchenne muscular …

Cross-sectional study into age-related pathology of mouse models for limb girdle muscular dystrophy types 2D and 2F

IEC Verhaart, K Putker, D van de Vijver… - PLoS …, 2019 - journals.plos.org
Limb girdle muscular dystrophy (LGMD) types 2D and 2F are caused by mutations in the
genes encoding for α-and δ-sarcoglycan, respectively, leading to progressive muscle …

Antagonism of the Thromboxane‐Prostanoid Receptor as a Potential Therapy for Cardiomyopathy of Muscular Dystrophy

JD West, CL Galindo, K Kim, JJ Shin… - Journal of the …, 2019 - Am Heart Assoc
Background Muscular dystrophy (MD) causes a progressive cardiomyopathy characterized
by diffuse fibrosis, arrhythmia, heart failure, and early death. Activation of the thromboxane …

Nonclinical Exon Skipping Studies with 2′-O-Methyl Phosphorothioate Antisense Oligonucleotides in mdx and mdx-utrn−/− Mice Inspired by Clinical Trial Results

M van Putten, C Tanganyika-de Winter… - nucleic acid …, 2019 - liebertpub.com
Duchenne muscular dystrophy is a severe, progressive muscle-wasting disease that is
caused by mutations that abolish the production of functional dystrophin protein. The exon …

Effects of chronic intake of a low concentration of Taurine on physical strength and body composition in mice

KS Cho, MK Neog, JY Kim, HI Yang, KS Kim - Taurine 11, 2019 - Springer
Most studies of taurine on athletic performance have been conducted at acute and high
doses in rodents. These doses and duration of administration are not reasonable for normal …

[PDF][PDF] Terapia farmacológica com deflazacorte e omega-3 na distrofinopatia de camundongos mdx exercitados na esteira

PAS SUAREZ - repositorio.unicamp.br
RESUMO A distrofia muscular de Duchenne (DMD) é caracterizada pela falta da distrofina.
Em ausência de distrofina ocorre instabilidade do sarcolema, entrada excessiva de cálcio e …

Characterization of Wilms' Tumour 1 (Wt1) as a Biomarker for Fibrosis in Duchenne Muscular Dystrophy

P Murphy - 2019 - search.proquest.com
Duchenne muscular dystrophy (DMD) is the most common inherited pediatric muscle
dystrophy. It is characterized by muscle degeneration, resulting in fibrosis that is a significant …

[PDF][PDF] Characterisation of the expression of dystrophin isoforms in cerebellar circuitry and their contribution to the plasticity of neurotransmitter receptors, immune …

T Jackson - 2019 - researchportal.port.ac.uk
Patients of the fatal neuromuscular disorder Duchenne Muscular Dystrophy (DMD)
frequently present with complex intellectual and neuropsychiatric comorbidities that are …

La communication os-muscle dans la dystrophie musculaire: une interaction musculaire hors triade pour l'ostéoprotégérine

A Boulanger Piette - 2019 - library-archives.canada.ca
La dystrophie musculaire de Duchenne est caractérisée par une dégénérescence
musculaire progressive accompagnée d'une fragilité osseuse exacerbée par la norme de …